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Table 1 Characteristics of study patients

From: Comparison of preoperative two-dimensional shear wave elastography, indocyanine green clearance test and biomarkers for post hepatectomy liver failure prediction in patients with hepatocellular carcinoma

Variable All patients (n = 215) Development cohort Validation cohort P value*
Patients without PHLF (n = 133) Patients with PHLF (n = 17) P value Patients without PHLF (n = 59) Patients with PHLF (n = 6) P value
Age (years) 54 ± 11 55 ± 10 52 ± 11 0.528 52 ± 9 54 ± 11 0.366 0.556
Numbers of male patients (%) 179 (83.2) 119 (89.5) 15 (88.2) 0.876 51 (86.4) 5 (83.3) 0.834 0.504
Body mass index (kg/m2) 23.0 ± 3.2 23.2 ± 3.3 21.5 ± 2.3 0.060 22.7 ± 3.0 22.3 ± 2.7 0.320 0.679
Serum biomarker levels         
 Platelet count (109/L) 137 143 147 0.921 138 141 0.098 0.053
 TB (μ mol/L) 14.3 14.3 15.1 0.785 14.2 14.7 0.112 0.685
 AST (U/L) 34 34 41 0.232 33 40 0.304 0.656
 ALT (U/L) 33 33 34 0.787 32 45 0.145 0.966
 Albumin (g/L) 42.2 42.2 38.5 0.170 42.7 39.2 0.169 0.521
 INR 1.03 1.03 1.05 0.171 1.06 1.04 0.765 0.072
Histological inflammation grade
 G0 20 14 3 0.547 3 0 0.910 0.415
 G1 55 35 2   16 2   
 G2 87 51 7   26 3   
 G3 53 33 5   14 1   
Fibrosis stage
 S0 21 13 1 0.567 7 0 0.670 0.757
 S1 10 6 0   3 1   
 S2 32 21 1   9 1   
 S3 52 30 4   17 1   
 S4 100 63 11   23 3   
Tumor size > 5 cm (%) 91 (42.3) 47 (35.3) 9 (52.9) 0.158 31 (52.5) 4 (66.7) 0.508 0.024
Operative factors
 Hilar occlusion (min) 14 14 15 0.378 13 14 0.102 0.067
 Operative time (min) 256 256 254 0.138 254 251 0.645 0.122
 Blood loss (mL) 300 300 400 0.059 200 300 0.496 0.061
  1. Data were described as means ± standard deviations or medians as appropriate. Comparison between patients with and without post hepatectomy liver failure (PHLF) groups was conducted respectively in the development cohort and validation cohort. Asterisk (*) revealed comparison between development cohort and validation cohort
  2. TB = total bilirubin; AST = aspartate transaminase; ALT = alanine aminotransferase; INR = international normalized ratio of prothrombin time