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Table 1 Summary of literature reporting on pancreatitis-induced TCM.

From: Takotsubo cardiomyopathy complicating acute pancreatitis: a case report

Authors Sankri-Tarbichi et al. [3] Rajani et al. [5] Cheezum et al. [6] Pednekar & Chandra [7] Leubner et al. [8] Bruenjas et al. [9] Boulos [10] Garbowska et al. [11] Koop et al. [12] Abe et al. [4] Ashraf et al. [13] Current case
Age (years) 56 72 76 70 76 55 47 47 63 57 64 27
Sex Female Female Female Female Female Male Female Female Male Female Female Male
Aetiology of pancreatitis Gallstones Gallstones Gallstones Alcohol Alcohol Gallstones Alcohol Unknown Alcohol
Symptoms of pancreatitis RUQ pain, nausea Abdominal pain N + V RUQ pain Epigastric pain, N + V Epigastric pain, N + V Epigastric pain Epigastric pain, N + V Epigastric pain, N + V Abdominal pain, N + V Epigastric pain, vomiting Epigastric pain, N + V diaphoresis
Time to TCM 3 days 7 days 2 days Same day 1 day Same day 7 days 3 days 4 days 5 days Same day
Systemic inflammation WCC 23.3 × 109/L Mild leukocytosis WCC 19.52 × 109/L, CRP 293.8 mg/L WCC 11.5 × 109/L WCC 14.6 × 109/L WCC 17.2 × 109/L
Symptoms of TCM SOB, chest pain, nausea Chest pain Tachypnoea, hypoxemic Cardiac arrest SOB, diaphoresis Chest pain, diaphoresis, nausea Nausea Chest pain, SOB Oliguria, hypotension, SOB, PEA arrest SOB, hypoxemic SOB Chest pain
Troponin (ng/mL; reference < 0.02) 2.39 0.32 0.67 3.13 9.94 0.66 0.3 9.65 0.02 0.97 Elevated 1019.63
ECG TWI V2-5 Inferolateral TWI Lateral ST elevation Inferior ST elevation, anterior TWI Anteroseptal ST elevation Generalised ST depression + TWI Inferolateral TWI ST elevation V2 Non-specific inferolateral T-wave changes Diffuse ischemic TWI Anterior ST elevation Anterior ST elevation
Chest radiography Pulmonary oedema Pulmonary oedema, bilateral pleural effusions Mild pulmonary oedema, bilateral pleural effusions Pulmonary congestion Acute pulmonary oedema Pulmonary oedema Pulmonary oedema
Echocardiogram or ventriculography LVEF 25%, severe apical hypokinesia/ akinesia of left ventricle, hypercontractile base Apical akinesis LVEF 30%, severe apical hypokinesis + hyperdynamic basal contraction LVEF 30% LVEF 30–35%, hypokinetic apical left ventricle LVEF 25%, apical ballooning, hypercontractile basal segments Akinesis of distal anterior, lateral, inferior walls of left ventricle LVEF 25%, apical ballooning, hypercontractile basal segments of left ventricle LVEF 20–25%, new-onset cardiomyopathy, global hypokinesis LVEF 40%, basal segment hyperkinesis, apical akinesis LVEF 30–35%, mid-to-apical segments hypokinetic to akinetic LVEF 20%, basal hyperkinesis, apical akinesis
Angiography Normal coronary arteries Unobstructed coronary arteries Mild non-obstructive CAD No obstructive atherosclerotic disease No CAD No obstructive CAD Not done—myocardial nuclear stress test mildly abnormal Normal coronary arteries 50% LAD stenosis, otherwise no obstructive CAD Normal coronary arteries Only luminal irregularities Non-obstructive CAD
Treatment of TCM Aspirin, BB, ACEi BB, ACEi BB, ACEi BB, ACEi Aspirin, BB, ACEi, warfarin Left ventricular assist device BB, ACEi BB, ACEi BB, ACEi
Recovery of LVEF Yes Yes Yes Yes Yes Yes No Yes
Time to recovery 10 days 2 weeks 6 weeks 3 weeks 10 days 3 weeks 6 weeks
  1. TCM Takotsubo cardiomyopathy; N + V nausea and vomiting; WCC white cell count; CRP C-reactive protein; SOB shortness of breath; PEA pulse electrical activity; TWI T-wave inversion; LVEF left ventricle ejection fraction; CAD coronary artery disease; LAD left anterior descending; BB beta-blocker; ACEi angiotensin-converting enzyme inhibitor