Fig. 4
Parameters of permeability of intestinal biopsies in Ctrl, UCActive, and UCRem. a Electrical resistances of colon biopsies of Ctrl, UCActive, and UCRem. UCRem showed the same level of transepithelial resistance (Rt equivalent to TER), epithelial (Repi), and subepithelial resistance (Rsub) as in Ctrl (Ctrl: Rt = 37.89 ± 3.02 Ω · cm2, Repi = 30.62 ± 3.79 Ω · cm2, Rsub = 7.26 ± 0.85 Ω · cm2, n = 5; UCRem: Rt = 41.08 ± 2.65 Ω · cm2, Repi = 31.45 ± 2.53 Ω · cm2, Rsub = 9.63 ± 1.03 Ω · cm2, n = 14). UCActive has lower Repi (17.8 ± 2.53 Ω · cm2, n = 3) compared with Ctrl (*p < 0.05) and UCRem (*p < 0.05), together with an increasing, albeit not significant, tendency of Rsub (14.29 ± 2.69 Ω · cm2, n = 3) leading to the same level of Rt (32.09 ± 7.00 Ω · cm2, n = 3). b Permeability for fluorescein. In Ctrl and UCRem, the permeability stayed at the same range, both of which are lower than in UCActive (Ctrl: 3.15 ± 1.09 × 10–6 cm · s−1, n = 8; UCRem: 4.82 ± 0.65 × 10–6 cm · s−1, n = 11; UCActive: 12.29 ± 1.53 × 10–6 cm · s−1, n = 6, ***p < 0.001). c Permeability for FD4. Similar results were observed that UCActive had higher permeability than Ctrl and UCRem (Ctrl: 3.10 ± 0.87 × 10–6 cm · s−1, n = 8; UCRem: 2.81 ± 0.57 × 10–6 cm · s−1, n = 15; UCActive: 12.91 ± 2.50 × 10–6 cm · s−1, n = 6, ***p < 0.001)