From: Economic burden of non-alcoholic steatohepatitis with significant fibrosis in Thailand
Parameters | Base-case values | SE | References |
---|---|---|---|
Prevalence (NAFLD) in general population | |||
Age 18–39 | 0.353 | 0.013 | |
Age 40–59 | 0.348 | 0.002 | |
Age 60 +  | 0.244 | 0.004 | |
Prevalence (NASH with significant fibrosis) in NAFLD | |||
Age 18–29 | 0.183 | 0.009 | |
Age 30–39 | 0.224 | 0.011 | |
Age 40–49 | 0.169 | 0.009 | |
Age 50–59 | 0.164 | 0.008 | |
Age 60–69 | 0.152 | 0.008 | |
Age 70–79 | 0.090 | 0.005 | |
Age 80 +  | 0.090 | 0.005 | |
Transitional probabilities | |||
Progression | |||
 Normal > F0 |  |  | [15] |
  Age 18–39 | 0.00140 |  |  |
  Age 40–59 | 0.00407 |  |  |
  Age 60–89 | 0.00515 |  |  |
  Age 90 +  | 0.00150 |  |  |
F0 > F1 | 0.090 | 0.026 | [27] |
F1 > F2 | 0.140 | 0.036 | [27] |
F2 > F3 | 0.070 | 0.020 | [27] |
F3 > F4/CC | 0.080 | 0.020 | [27] |
F4 > DC | 0.060 | 0.010 | [27] |
F4 > HCC | 0.030 | 0.012 | |
DC > HCC | 0.030 | 0.01173 | |
DC > LT | 0.0003 | 0.00002 | |
HCC > LT | 0.0016 | 0.00008 | |
HCC > Death | 0.4490 | 0.02959 | |
LT > post-LT | 0.7993 | NA |  |
LT > Death | 0.2007 | 0.01024 | |
Post-LT > Death | 0.0653 | 0.00333 | |
Regression | |||
F0 > normal | 0.000 |  | Assumption |
F1 > F0 | 0.080 | 0.026 | [27] |
F2 > F1 | 0.190 | 0.059 | [27] |
F3 > F2 | 0.200 | 0.087 | [27] |
F4 > F3 | 0.120 | 0.023 | [27] |
Direct medical costs (2019 $) | |||
NASH | 89 | 11 | [40] |
CC | 2121 | 271 | [41] |
DC | 3916 | 499 | [41] |
HCC | 4787 | 622 | [41] |
LT | 18,703 | 2298 | [41] |
post-LT | 2908 | 371 | [41] |