Fig. 1

Receiver operating characteristic (ROC) analysis of the NGS Panel, AFP and AFP + NGS Panel. ROC curves for the NGS panel (black), AFP (red) and combination of NGS panel with AFP (blue) using logistic regression for 60 HCC versus 102 controls in the testing set. Areas under the curve (AUC) are written at the bottom right using the corresponding colors. Selected sensitivity/specificity pairs indicated on the curves are reported AFP ≥ 20 ng/mL, the NGS panel using the trained algorithm, and the post hoc combination of the NGS panel and AFP