Table 3 Gene expression of inflammatory cytokines in each of the gastro-esophageal reflux disease phenotypes compared with the control group and in the non-erosive subgroup
IL-1β Mean ± SEM p value | IL-6 Mean ± SEM p value | IL-8 Mean ± SEM p value | IL-10 Mean ± SEM p value | INF-γ Mean ± SEM p value | TNF-α Mean ± SEM p value | MMP3 Mean ± SEM p value | MMP9 Mean ± SEM p value | |
|---|---|---|---|---|---|---|---|---|
Barrett’s Esophagus versus Control | 0.057 ± 0.050 N.S | 0.002 ± 0.005 N.S | 0.24 ± 0.01 0.010 | 0.024 ± 0.025 N.S | 0.05 ± 0.04 N.S | 0.04 ± 0.03 N.S | 0.018 ± 0.033 N.S | 0.023 ± 0.04 N.S |
Erosive esophagitisversus Control | 0.46 ± 0.031 0.003 | 0.03 ± 0.002 0.020 | 0.010 ± .007 N.S | 0.010 ± 0.009 0.043 | 0.001 ± 0.003 N.S | 0.002 ± 0.001 N.S | 0.003 ± 0.002 N.S | 0.003 ± 0.002 N.S |
Abnormal acid exposure versus Control | 0.19 ± 0.10 0.0001 | 0.057 ± 0.047 0.012 | 0.023 ± 0.017 N.S | 0.01 ± 0.01 N.S | 0.018 ± 0.013 0.001 | 0.049 ± 0.028 0.0001 | 0.009 ± 0.007 N.S | 0.005 ± 0.001 N.S |
Abnormal acid exposure versus Normal Acid Exposure | 0.16 ± 0.10 0.001 | 0.04 ± 0.05 N.S | 0.011 ± 0.023 N.S | 0.001 ± 0.003 N.S | 0.004 ± 0.014 N.S | 0.03 ± 0.030 0.036 | 0.03 ± 0.09 N.S | 0.006 ± 0.005 N.S |