Role of percutaneous liver biopsy in infantile cholestasis: cohort from Arabs

BMC Gastroenterology

Table 2 The histological description of the 3 confirmed biliary atresia cases mislabeled as non-BA

	Age at LB (days)	Histology on percutaneous LB	Wedge LB	US liver	MRI liver	IOC
1	60	No significant BD proliferation. No BD plugs. BD injury with few vanished BD. Moderate portal fibrosis. Canalicular cholestasis. Pathologist suggested neonatal sclerosing cholangitis	Marked BD proliferation. BD plugs. BD injury not seen. Fibrous septae and marked portal fibrosis	CBD visualized. Normal GB size	Hypoplastic GB	Failed due to atrophic GB
2	90	Mild BD proliferation. No BD plugs. Marked portal fibrosis with septae. Hepatocytes swelling. GC transformation. Canalicular cholestasis. Pathologist suggested BASD and PFIC 2	ND	CBD non-visualized Echogenic cord sign GB non-visualized	CBD non-visualized GB non-visualized	ND*
3^‡	60	Mild BD proliferation. No BD plugs. Marked portal fibrosis with septae. Hepatocytes ballooning. Canalicular cholestasis. Pathologist suggested BASD and PFIC 3	ND	CBD non-visualized GB atrophic	CBD non-visualized GB non-visualized	ND*

LB liver biopsy, US ultrasound, MRI magnetic resonance image, IOC intraoperative cholangiogram, BD bile ducts, CBD common bile duct, GB gall bladder, GC giant cell, BASD bile acid synthesis disorder, PFIC progressive familial intrahepatic cholestasis, ND not done, ND* not done because of late presentation, the child underwent liver transplantation and biliary atresia was confirmed intraoperatively
^‡Patient has heterotaxy syndrome, intrahepatic interruption of inferior vena cava, hemi-azygous continuation, and the superior mesenteric vein was seen anterior to the superior mesenteric artery

ISSN: 1471-230X