Table 4 Risk factors associated with histological upgrade to ESCC in patients diagnosed with HGIN on biopsy
Variables | Total (n = 83) | Final histology | p value | |
|---|---|---|---|---|
Non-ESCC (n = 49) | ESCC (n = 34) |  | ||
Age(years) | Â | Â | Â | 0.654 |
 < 60 | 27 (32.5) | 15 (30.6) | 12 (35.3) |  |
 ≥ 60 | 56 (67.5) | 34 (69.4) | 22 (64.7) |  |
Sex | Â | Â | Â | 0.326 |
 Male | 56 (67.5) | 31 (63.3) | 25 (73.5) |  |
 Female | 27 (32.5) | 18 (36.7) | 9 (26.5) |  |
Lesion size (mm) | Â | Â | Â | 0.001 |
 < 10 | 13 (15.7) | 13 (26.5) | 0 (0) |  |
 10–20 | 27 (32.5) | 17 (34.7) | 10 (29.4) |  |
 ≥ 20 | 43 (51.5) | 19 (38.8) | 24 (70.6) |  |
Circumferential extent of lesions | Â | Â | Â | 0.159 |
 < 50% | 74 (89.2) | 45 (91.8) | 29 (85.3) |  |
 50–75% | 7 (8.4) | 4 (8.2) | 3 (8.8) |  |
 > 75% | 2 (2.4) | 0 (0) | 2 (5.9) |  |
Location | Â | Â | Â | 0.018 |
 Upper esophagus | 8 (19.7) | 4 (8.2) | 4 (11.8) |  |
 Middle esophagus | 65 (78.3) | 43 (87.7) | 22 (64.7) |  |
 Lower esophagus | 10 (12.0) | 2 (4.1) | 8 (23.5) |  |
Color | Â | Â | Â | Â |
 Reddish | 55 (66.3) | 32 (65.3) | 23 (67.6) | 0.090 |
 Whitish | 15 (18.1) | 8 (16.3) | 7 (20.6) |  |
 No obvious change | 10 (12.0) | 9 (18.4) | 1 (2.8) |  |
Gross type | Â | Â | Â | 0.073 |
 Elevated | 2 (2.4) | 0 (0) | 2 (5.9) |  |
 Flat | 64 (77.1) | 41 (83.7) | 23 (67.6) |  |
 Depressed | 17 (20.5) | 8 (16.3) | 9 (26.5) |  |
Pink color sign | Â | Â | Â | 0.002 |
 Yes | 44 (53.0) | 19 (38.8) | 25 (73.5) |  |
 No | 39 (47.0) | 30 (61.2) | 9 (26.5) |  |
IPCL | Â | Â | Â | 0.266* |
 Type A | 3 (3.6) | 3 (6.1) | 0 (0) |  |
 Type B | 80 (96.4) | 46 (93.9) | 34 (100) |  |
Brownish color background | Â | Â | Â | Â 0.101 |
 Yes | 66 (79.5) | 36 (73.5) | 30 (88.2) |  |
 No | 17 (20.5) | 13 (26.5) | 4 (11.8) |  |
Number of biopsies | Â | Â | Â | 0.131 |
 1 | 61 (73.5) | 39 (79.6) | 22 (64.7) |  |
 ≥ 2 | 22 (26.5) | 10 (20.4) | 12 (35.3) |  |