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Table 3 Univariate and multivariate Cox regression analyses of risk factors for esophageal cancer

From: V-Raf murine sarcoma viral oncogene homolog B1 (BRAF) as a prognostic biomarker of poor outcomes in esophageal cancer patients

Variable

Univariate analysis

Multivariate analysis

HR

95%CI

P value

HR

95% CI

P value

Age (60 y vs. > 60 y)

0.949

0.604–1.492

0.820

   

Gender

1.739

1.032–2.931

0.038

1.884

1.039–3.133

0.036

T stage (T1 vs. T2–4)

5.526

1.353–22.574

0.017

1.137

0.149–8.949

0.903

N stage (N0 vs. N1–3)

1.850

1.192–2.870

0.006

1.374

0.868–2.176

0.176

AJCC clinical staging (I vs. II–III)

9.119

1.265–65.707

0.028

7.383

0.417–134.348

0.172

Pathological grading (I vs. II–III)

1.234

0.752–2.024

0.405

   

Ki67 (< 14% vs. ≥ 14%)

1.539

0.893–2.653

0.120

   

BRAF (weakly vs. strongly)

2.087

1.131–3.853

0.019

2.782

1.444–5.361

0.002