Table 6 GRADE assessment of included outcomes for PDRI and P-PASS
| Outcome | Risk index | Studies^ | GRADE quality | Footnotes* | Interpretation |
|---|---|---|---|---|---|
| 1-year pancreas survival | PDRI as a continuous score | 4 | ⊕ VERY LOW |
2 studies demonstrated an association with outcome Downgraded for: Outcomes differing between studies (INCONSISTENCY) | Very low quality evidence that PDRI as a continuous variable is associated with 1-year pancreas survival |
| PDRI as quintiles | 4 | ⊕⊕ LOW |
3 of 4 studies demonstrated an association with the outcome Association with SPK transplants in 2 studies | Low quality evidence that PDRI in quartiles is associated with 1-year pancreas survival (particularly SPK transplants) | |
| PDRI as categorical model (various risk groups) | 5 | ⊕ VERY LOW |
1 of 5 studies demonstrated an association with outcome Downgraded for: Differing PDRI risk groups (INDIRECTNESS) Outcomes differing between studies (INCONSISTENCY) Small total event rate < 300 (IMPRECISION) | Very low quality evidence that PDRI as a categorical model (by various risk groups) is associated with 1-year pancreas survival | |
| 1-year patient survival | PDRI as tertiles | 1 | ⊕ VERY LOW |
No association with outcome Downgraded for: Small number of studies (IMPRECISION) | Very low quality evidence that PDRI by tertiles is associated with 1-year patient survival |
| Donor pancreas acceptance | P-PASS < 17vs ≥ 17 | 4 | ⊕⊕ LOW | All studies demonstrated an association with outcome | Low quality evidence that P-PASS is associated with donor pancreas acceptance |