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Table 5 Factors associated with significant liver fibrosis in patients with HCV (n = 365)

From: The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C

 

Univariate analysis

Multivariate analysis

Variable

OR

95% CI

P value

OR

95% CI

P value

Age (years)

1.075

1.054–1.097

 < .0001*

1.103

1.073—1.134

 < .0001*

Men /Women (n)

1.158

0.753–1.782

0.5037

   

Type 2 diabetes (n)

2.532

1.412–4.545

0.0018*

   

Dyslipidemia (n)

2.188

1.195–4.000

0.0112*

   

High-blood pressure (n)

2.976

1.859–4.762

 < .0001*

   

Obesity (BMI ≥ 30) (n)

1.086

0.674–1.748

0.7358

   

Metabolic syndrome (n)

2.299

1.294–4.082

0.0046*

   

Hypothyroidism (n)

1.869

0.999–3.497

0.0504

   

Previous alcohol use (n)

1.089

0.493–2.404

0.8325

   

HOMA-IR value ≥ 2.5 (n)

1.773

1.149–2.732

0.0096*

   

AST (U/L)

1.025

1.016–1.034

 < .0001*

   

ALT (U/L)

1.025

1.017–1.033

 < .0001*

1.028

1.017–1.038

 < .0001*

Alkaline phosphatase (U/L)

1.029

1.018–1.040

 < .0001*

1.019

1.006–1.032

0.0043*

GGT (U/L)

1.007

1.003–1.010

 < .0001*

   

Creatinine (mg/dL)

1.183

0.720–1.943

0.5065

   

Total cholesterol (mg/dL)

0.988

0.982–0.995

0.0002*

0.975

0.965–0.984

 < .0001*

HDL (mg/dL)

0.993

0.980–1.006

0.2949

   

LDL (mg/dL)

0.987

0.980–0.994

0.0004*

   

Triglycerides (mg/dL)

0.997

0.993–1.001

0.1454

   

PNPLA3 C / G allele (n)

1.013

0.659–1.557

0.9524

   

TM6SF2 CT + TT / CC (n)

1.953

1.009–3.788

0.0471*

   
  1. Logistic regression
  2. ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; CI: confidence interval; GGT: gamma glutamyl transferase; HCV: hepatitis C virus; HDL: high-density lipoprotein; HOMA-IR: Homeostatic Model of Assessment; LDL: low-density lipoprotein; OR: odds ratio
  3. *p value < 0.05
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BMC Gastroenterology

ISSN: 1471-230X

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