| |
CC
|
CT/TT% / (n) or mean ± SD
|
P value
|
|---|
|
Age (years)
|
55.17 ± 12.66
|
48.88 ± 11.87
|
0.002*
|
|
Men /Women (n)
|
44.1% (142)/55.9% (180)
|
52.5% (21)/47.5% (19)
|
0.313
|
|
Race
| | | |
|
White
|
76.7% (247)
|
75% (30)
|
0.757
|
|
Multiracial (Brown)
|
13.7% (44)
|
17.5% (7)
| |
|
Black
|
9.6% (31)
|
7.5% (3)
| |
|
Type 2 diabetes (n)
|
24.4% (77)
|
15% (6)
|
0.186
|
|
Dyslipidemia (n)
|
21.6% (68)
|
10% (4)
|
0.086
|
|
High-blood pressure (n)
|
45.3% (143)
|
27.5% (11)
|
0.032*
|
|
Obesity (BMI ≥ 30) (n)
|
31.6% (100)
|
15% (6)
|
0.030*
|
|
BMI
|
27.7 ± 5.21
|
26.59 ± 3.24
|
0.274
|
|
Metabolic syndrome (n)
|
25.3% (80)
|
7.7% (3)
|
0.014*
|
|
Hypothyroidism (n)
|
17.4% (55)
|
17.5% (7)
|
0.988
|
|
Previous alcohol use (n)
|
8.2% (26)
|
10% (4)
|
0.760
|
|
HOMA-IR value ≥ 2.5 (n)
|
53.1% (171)
|
50% (20)
|
0.710
|
|
HOMA-IR
|
3.26 ± 4.31
|
2.69 ± 3.86
|
0.414
|
|
AST (U/L)
|
63.11 ± 51.51
|
60.65 ± 42.02
|
0.897
|
|
ALT (U/L)
|
68.76 ± 52.21
|
68.33 ± 44.48
|
0.760
|
|
Alkaline phosphatase (U/L)
|
84.19 ± 35.34
|
74.05 ± 27.46
|
0.041*
|
|
GGT (U/L)
|
104.16 ± 113.22
|
84.26 ± 83.48
|
0.276
|
|
Creatinine (mg/dL)
|
0.87 ± 0.33
|
1.01 ± 1.57
|
0.091
|
|
Total cholesterol (mg/dL)
|
158.24 ± 35.06
|
147.33 ± 42.32
|
0.036*
|
|
HDL (mg/dL)
|
52.27 ± 16.12
|
49.67 ± 15.88
|
0.516
|
|
LDL (mg/dL)
|
85.69 ± 30.67
|
79.31 ± 36.08
|
0.117
|
|
Triglycerides (mg/dL)
|
103.05 ± 54.03
|
91.05 ± 37.1
|
0.205
|
|
Liver histology
| | | |
|
Fibrosis (n) 0–1
|
33.9% (109)
|
50% (20)
| |
|
2–4
|
66.1% (213)
|
50% (20)
|
0.044*
|
|
Inflammation (n) 0–1
|
46.7% (122)
|
43.2% (16)
| |
|
2–3
|
53.3% (139)
|
56.8% (21)
|
0.689
|
|
Steatosis (n) 0
|
45.3% (145)
|
40% (16)
| |
|
1–3
|
54.7% (175)
|
60% (24)
|
0.524
|
- Chi-square test, Fisher's exact test, Mann–Whitney, and Kruskal–Wallis test
- ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; HCV: hepatitis C virus; HDL: high-density lipoprotein; HOMA-IR: Homeostatic Model of Assessment; LDL: low-density lipoprotein; GGT: gamma glutamyl transferase; SD: standard deviation
- *p value < 0.05
