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Table 4 Characteristics of patients with HCV according to TM6SF2 polymorphisms (n = 362)

From: The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C

  CC CT/TT% / (n) or mean ± SD P value
Age (years) 55.17 ± 12.66 48.88 ± 11.87 0.002*
Men /Women (n) 44.1% (142)/55.9% (180) 52.5% (21)/47.5% (19) 0.313
Race    
  White 76.7% (247) 75% (30) 0.757 
  Multiracial (Brown) 13.7% (44) 17.5% (7)  
  Black 9.6% (31) 7.5% (3)  
Type 2 diabetes (n) 24.4% (77) 15% (6) 0.186
Dyslipidemia (n) 21.6% (68) 10% (4) 0.086
High-blood pressure (n) 45.3% (143) 27.5% (11) 0.032*
Obesity (BMI ≥ 30) (n) 31.6% (100) 15% (6) 0.030*
BMI 27.7 ± 5.21 26.59 ± 3.24 0.274
Metabolic syndrome (n) 25.3% (80) 7.7% (3) 0.014*
Hypothyroidism (n) 17.4% (55) 17.5% (7) 0.988
Previous alcohol use (n) 8.2% (26) 10% (4) 0.760
HOMA-IR value ≥ 2.5 (n) 53.1% (171) 50% (20) 0.710
HOMA-IR 3.26 ± 4.31 2.69 ± 3.86 0.414
AST (U/L) 63.11 ± 51.51 60.65 ± 42.02 0.897
ALT (U/L) 68.76 ± 52.21 68.33 ± 44.48 0.760
Alkaline phosphatase (U/L) 84.19 ± 35.34 74.05 ± 27.46 0.041*
GGT (U/L) 104.16 ± 113.22 84.26 ± 83.48 0.276
Creatinine (mg/dL) 0.87 ± 0.33 1.01 ± 1.57 0.091
Total cholesterol (mg/dL) 158.24 ± 35.06 147.33 ± 42.32 0.036*
HDL (mg/dL) 52.27 ± 16.12 49.67 ± 15.88 0.516
LDL (mg/dL) 85.69 ± 30.67 79.31 ± 36.08 0.117
Triglycerides (mg/dL) 103.05 ± 54.03 91.05 ± 37.1 0.205
Liver histology    
  Fibrosis (n) 0–1 33.9% (109) 50% (20)  
  2–4 66.1% (213) 50% (20) 0.044* 
  Inflammation (n) 0–1 46.7% (122) 43.2% (16)  
  2–3 53.3% (139) 56.8% (21) 0.689 
  Steatosis (n) 0 45.3% (145) 40% (16)  
  1–3 54.7% (175) 60% (24) 0.524 
  1. Chi-square test, Fisher's exact test, Mann–Whitney, and Kruskal–Wallis test
  2. ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; HCV: hepatitis C virus; HDL: high-density lipoprotein; HOMA-IR: Homeostatic Model of Assessment; LDL: low-density lipoprotein; GGT: gamma glutamyl transferase; SD: standard deviation
  3. *p value < 0.05