| |
CC
|
CG % / (n) or mean ± SD
|
GG
|
P value
|
|---|
|
Age (years)
|
53.75 ± 12.9
|
55.94 ± 12.52
|
52.04 ± 12.03
|
0.191
|
|
Men /Women (n)
|
48.7% (91)/51.3% (96)
|
42% (63)/58% (87)
|
33.3% (9)/66.7% (18)
|
0.218
|
|
Race
| | | | |
|
White
|
75.9% (142)
|
77.3% (116)
|
77.8% (21)
|
0.699
|
|
Multiracial (Brown)
|
15.5% (29)
|
13.3% (20)
|
7.4% (2)
| |
|
Black
|
8.6% (16)
|
9.3% (14)
|
14.8% (4)
| |
|
Type 2 diabetes (n)
|
23.4% (43)
|
25.7% (38)
|
7.7% (2)
|
0.133
|
|
Dyslipidemia (n)
|
21.2% (39)
|
21.1% (31)
|
3.9% (1)
|
0.103
|
|
High-blood pressure (n)
|
42.9% (79)
|
45.3% (67)
|
38.4% (10)
|
0.786
|
|
Obesity (BMI ≥ 30) (n)
|
30.8% (57)
|
30.4% (45)
|
15.4% (4)
|
0.259
|
|
BMI
|
27.67 ± 4.94
|
27.9 ± 5.24
|
25.19 ± 3.7
|
0.046* (GG < CG/CC)
|
|
Metabolic syndrome (n)
|
25.7% (47)
|
24.3% (36)
|
0% (0)
|
0.013*
|
|
Hypothyroidism (n)
|
17.4% (32)
|
16.9% (25)
|
19.2% (5)
|
0.958
|
|
Previous alcohol use (n)
|
8.7% (16)
|
7.4% (11)
|
7.7% (2)
|
0.913
|
|
HOMA-IR value ≥ 2.5 (n)
|
51.9% (97)
|
55.3% (83)
|
44.4% (12)
|
0.547
|
|
HOMA-IR
|
3.19 ± 4.65
|
3.33 ± 3.94
|
2.46 ± 2.71
|
0.293
|
|
AST (U/L)
|
66.11 ± 59.4
|
59.62 ± 37.57
|
66.63 ± 51.98
|
0.929
|
|
ALT (U/L)
|
71.82 ± 55.08
|
64.68 ± 43.82
|
73 ± 62.14
|
0.505
|
|
Alkaline phosphatase (U/L)
|
84.61 ± 33.1
|
82.71 ± 38.26
|
73.26 ± 20.73
|
0.196
|
|
GGT (U/L)
|
103.74 ± 115.94
|
104.09 ± 110.33
|
78.89 ± 62.5
|
0.761
|
|
Creatinine (mg/dL)
|
0.9 ± 0.77
|
0.87 ± 0.35
|
0.88 ± 0.39
|
0.956
|
|
Total cholesterol (mg/dL)
|
157.32 ± 37.85
|
158.26 ± 35.08
|
151.96 ± 29.2
|
0.752
|
|
HDL (mg/dL)
|
51.34 ± 16.01
|
52.32 ± 16.52
|
56.33 ± 17.43
|
0.466
|
|
LDL (mg/dL)
|
85.21 ± 32.12
|
85.89 ± 30.46
|
79.22 ± 30.06
|
0.541
|
|
Triglycerides (mg/dL)
|
104.16 ± 46.95
|
101.93 ± 60.93
|
86.7 ± 34.53
|
0.117
|
|
Liver histology
| | | | |
|
Fibrosis (n) 0–1
|
35.3% (66)
|
35.3% (53)
|
37.0% (10)
| |
|
2–4
|
64.7% (121)
|
64.7% (97)
|
63.0% (17)
|
0.983
|
|
Inflammation (n) 0–1
|
44.2% (69)
|
46.6% (55)
|
52% (13)
| |
|
2–3
|
55.8% (87)
|
53.4% (63)
|
48% (12)
|
0.750
|
|
Steatosis (n) 0
|
48.7% (91)
|
41.2% (61)
|
33.3% (9)
| |
|
1–3
|
51.3% (96)
|
58.8% (87)
|
66.7% (18)
|
0.190
|
- Chi-square test, Fisher's exact test, Mann–Whitney, and Kruskal–Wallis test
- ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; HCV: hepatitis C virus; HDL: high-density lipoprotein; HOMA-IR: Homeostatic Model of Assessment; LDL: low-density lipoprotein; GGT: gamma glutamyl transferase; SD: standard deviation
- *p value < 0.05
