Table 3 Characteristics of patients with HCV according to PNPLA3 polymorphisms (n = 364)
CC | CG % / (n) or mean ± SD | GG | P value | |
|---|---|---|---|---|
Age (years) | 53.75 ± 12.9 | 55.94 ± 12.52 | 52.04 ± 12.03 | 0.191 |
Men /Women (n) | 48.7% (91)/51.3% (96) | 42% (63)/58% (87) | 33.3% (9)/66.7% (18) | 0.218 |
Race | ||||
White | 75.9% (142) | 77.3% (116) | 77.8% (21) | 0.699 |
Multiracial (Brown) | 15.5% (29) | 13.3% (20) | 7.4% (2) | |
Black | 8.6% (16) | 9.3% (14) | 14.8% (4) | |
Type 2 diabetes (n) | 23.4% (43) | 25.7% (38) | 7.7% (2) | 0.133 |
Dyslipidemia (n) | 21.2% (39) | 21.1% (31) | 3.9% (1) | 0.103 |
High-blood pressure (n) | 42.9% (79) | 45.3% (67) | 38.4% (10) | 0.786 |
Obesity (BMI ≥ 30) (n) | 30.8% (57) | 30.4% (45) | 15.4% (4) | 0.259 |
BMI | 27.67 ± 4.94 | 27.9 ± 5.24 | 25.19 ± 3.7 | 0.046* (GG < CG/CC) |
Metabolic syndrome (n) | 25.7% (47) | 24.3% (36) | 0% (0) | 0.013* |
Hypothyroidism (n) | 17.4% (32) | 16.9% (25) | 19.2% (5) | 0.958 |
Previous alcohol use (n) | 8.7% (16) | 7.4% (11) | 7.7% (2) | 0.913 |
HOMA-IR value ≥ 2.5 (n) | 51.9% (97) | 55.3% (83) | 44.4% (12) | 0.547 |
HOMA-IR | 3.19 ± 4.65 | 3.33 ± 3.94 | 2.46 ± 2.71 | 0.293 |
AST (U/L) | 66.11 ± 59.4 | 59.62 ± 37.57 | 66.63 ± 51.98 | 0.929 |
ALT (U/L) | 71.82 ± 55.08 | 64.68 ± 43.82 | 73 ± 62.14 | 0.505 |
Alkaline phosphatase (U/L) | 84.61 ± 33.1 | 82.71 ± 38.26 | 73.26 ± 20.73 | 0.196 |
GGT (U/L) | 103.74 ± 115.94 | 104.09 ± 110.33 | 78.89 ± 62.5 | 0.761 |
Creatinine (mg/dL) | 0.9 ± 0.77 | 0.87 ± 0.35 | 0.88 ± 0.39 | 0.956 |
Total cholesterol (mg/dL) | 157.32 ± 37.85 | 158.26 ± 35.08 | 151.96 ± 29.2 | 0.752 |
HDL (mg/dL) | 51.34 ± 16.01 | 52.32 ± 16.52 | 56.33 ± 17.43 | 0.466 |
LDL (mg/dL) | 85.21 ± 32.12 | 85.89 ± 30.46 | 79.22 ± 30.06 | 0.541 |
Triglycerides (mg/dL) | 104.16 ± 46.95 | 101.93 ± 60.93 | 86.7 ± 34.53 | 0.117 |
Liver histology | ||||
Fibrosis (n) 0–1 | 35.3% (66) | 35.3% (53) | 37.0% (10) | |
2–4 | 64.7% (121) | 64.7% (97) | 63.0% (17) | 0.983 |
Inflammation (n) 0–1 | 44.2% (69) | 46.6% (55) | 52% (13) | |
2–3 | 55.8% (87) | 53.4% (63) | 48% (12) | 0.750 |
Steatosis (n) 0 | 48.7% (91) | 41.2% (61) | 33.3% (9) | |
1–3 | 51.3% (96) | 58.8% (87) | 66.7% (18) | 0.190 |