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Table 1 Demographic, clinical and biochemical characteristics of patients with HCV

From: The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C

 

HCV patients (n = 365)

% (n) or mean ± SD

Age (years)

54.54 ± 12.7

Men /Women (n)

44.9% (164) / 55.1% (201)

Race (n)

 

  White

76.7% (280)

  Multiracial (Brown)

13.8% (51)

  Black

9.3% (34)

Type 2 diabetes (n)

23.1% (83/359)

Dyslipidemia (n)

20.1% (72/358)

High-blood pressure (n)

43.5% (156/359)

Obesity (BMI ≥ 30)

29.4% (106/360)

BMI

27.57 ± 5.02

Metabolic Syndrome (n)

23.2% (83/358)

Hypothyroidism (n)

17.3% (62/359)

Previous alcohol use (n)

8.4% (30/359)

Previous CVE (n)

5.0% (17/359)

HCV genotype (n)

 

  1

79.4% (289/364)

  2

2.2% (8/364)

  3

17.9% (65/364)

  4

0.5% (2/364)

HOMA-IR

3.18 ± 4.24

AST (U/L)

63.36 ± 50.84

ALT (U/L)

68.84 ± 51.27

Alkaline phosphatase (U/L)

83 ± 34.62

GGT (U/L)

102.07 ± 110.32

Creatinine (mg/dL)

0.89 ± 0.6

Total cholesterol (mg/dL)

157.25 ± 36.06

HDL (mg/dL)

52.11 ± 16.31

LDL (mg/dL)

85.01 ± 31.22

Triglycerides (mg/dL)

101.81 ± 52.5

Liver histology

 

 Fibrosis (n = 364)

 

  F0

7.4% (27)

  F1

28.0% (102)

  F2

18.1% (66)

  F3

15.9% (58)

  F4

30.5% (111)

  Inflammation (n = 300)

 

   A0

5.7% (17)

   A1

40.3% (121)

   A2

36.7% (110)

   A3

17.3% (52)

  Steatosis (n = 354)

 

   0

44.9% (159)

   1

32.5% (115)

   2

16.7% (59)

   3

5.9% (21)

  1. ALT: alanine aminotransferase; AST: aspartate aminotransferase; BMI: body mass index; CVE: cardiovascular event; HDL: high-density lipoprotein; HOMA-IR: Homeostatic Model of Assessment; LDL: low-density lipoprotein; GGT: gamma glutamyl transferase; HCV: hepatitis C virus; SD: standard deviation