Score | Criteria |
---|---|
0 (Normal) |  < 3 macrovesicular lipid vacuoles per lobule |
1 (Minimal) | 5–10% hepatocytes affected, midzonal location, no hepatocyte swelling, macrovesicular lipid vacuoles |
2 (Mild) | 10–25% hepatocytes affected, midzonal location with some centrilobular involvement, no or mild hepatocyte swelling, mainly macrovesicular lipid vacuolation with occasional microvesicular lipid vacuolation |
3 (Moderate) | 25–50% hepatocytes affected, midzonal and centrilobular distribution, moderate to marked hepatocyte swelling centrilobular and midzonal; minimal to mild swelling periportal, macro- and microvesicular lipid vacuoles |
4 (Marked) | 50–75% hepatocytes affected, midzonal, centrilobular and some periportal distribution, moderate to severe hepatocyte swelling, macro- and microvesicular lipid vacuolation |
5 (Severe) | 75–95% hepatocytes affected, midzonal, centrilobular and periportal distribution, severe hepatocyte swelling centrilobular and midzonal, moderate to marked swelling periportal, macro- and microvesicular vacuolation |
6 (Very Severe) | 95–100% hepatocytes affected, midzonal, centrilobular and periportal distribution, severe hepatocyte swelling all zones, macro- and microvesicular vacuolation |