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Table 2 Hepatic lipidosis scoring criteria

From: Development of a novel model of cholecystectomy in subsequently ovariectomized mice and characterization of metabolic and gastrointestinal phenotypes: a pilot study

Score

Criteria

0 (Normal)

 < 3 macrovesicular lipid vacuoles per lobule

1 (Minimal)

5–10% hepatocytes affected, midzonal location, no hepatocyte swelling, macrovesicular lipid vacuoles

2 (Mild)

10–25% hepatocytes affected, midzonal location with some centrilobular involvement, no or mild hepatocyte swelling, mainly macrovesicular lipid vacuolation with occasional microvesicular lipid vacuolation

3 (Moderate)

25–50% hepatocytes affected, midzonal and centrilobular distribution, moderate to marked hepatocyte swelling centrilobular and midzonal; minimal to mild swelling periportal, macro- and microvesicular lipid vacuoles

4 (Marked)

50–75% hepatocytes affected, midzonal, centrilobular and some periportal distribution, moderate to severe hepatocyte swelling, macro- and microvesicular lipid vacuolation

5 (Severe)

75–95% hepatocytes affected, midzonal, centrilobular and periportal distribution, severe hepatocyte swelling centrilobular and midzonal, moderate to marked swelling periportal, macro- and microvesicular vacuolation

6 (Very Severe)

95–100% hepatocytes affected, midzonal, centrilobular and periportal distribution, severe hepatocyte swelling all zones, macro- and microvesicular vacuolation