Table 2 Association of GRS with detailed features of colonoscopy outcomes
From: Polygenic risk score is a predictor of adenomatous polyps at screening colonoscopy
Variables | No. subjects | GRS, mean (95% CI) | OR (95% CI) | p |
|---|---|---|---|---|
No polyps or HP | 1249 | 0.97 (0.95–0.99) | 1 | |
Adenomatous polyps | 520 | 1.02 (1–1.05) | 1.61 (1.24–2.08) | < 0.001 |
Polyp size < 0.5 cm | 203 | 1.02 (0.97–1.06) | 1.49 (1.03–2.13) | 0.07 |
Polyp size ≥ 0.5 cm | 316 | 1.03 (1–1.07) | 1.68 (1.23–2.27) | < 0.001 |
Advanced adenoma | 126 | 1.02 (0.97–1.08) | 1.56 (0.99–2.42) | 0.10 |
Total no. of polyps | ||||
No. = 1 | 304 | 1.04 (1–1.07) | 1.77 (1.3–2.41) | < 0.001 |
No. > 1 | 216 | 1.01 (0.96–1.15) | 1.38 (0.96–1.96) | 0.14 |
Location | ||||
CA | 296 | 1.02 (0.98–1.06) | 1.56 (1.14–2.12) | 0.02 |
TD | 197 | 1.02 (0.97–1.06) | 1.49 (1.02–2.14) | 0.08 |
RS | 159 | 1.02 (0.97–1.08) | 1.57 (1.05–2.33) | 0.06 |