BMC Gastroenterology

Table 1 Univariable and multivariable analysis of OS and RFS in patients with PAAD

From: Expression and prognostic impact of FZDs in pancreatic adenocarcinoma

Variables	Univariable analysis				Multivariable analysis
	OS		RFS		OS		RFS
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Age, years	1.027 (1.006–1.049)	0.012	1.024 (0.974–1.077)	0.355	1.028 (1.005–1.051)	0.018	1.027 (0.964–1.095)	0.409
Gender
Male	Reference		Reference		Reference		Reference
Female	1.159 (0.768–1.750)	0.483	2.199 (0.924–5.236)	0.075	1.134 (0.729–1.764)	0.578	2.661 (0.916–7.729)	0.072
Grade
I + II	Reference		Reference		Reference		Reference
III + IV	1.512 (0.979–2.335)	0.062	1.367 (0.561–3.331)	0.491	1.199 (0.754–1.908)	0.443	1.278 (0.437–3.739)	0.654
FZD3
Low	Reference		Reference		Reference		Reference
High	0.647 (0.427–0.983)	0.041	0.705 (0.301–1.651)	0.421	0.639 (0.408–1.000)	0.048	0.323 (0.097–1.072)	0.065
FZD4
Low	Reference		Reference		Reference		Reference
High	0.783 (0.518–1.185)	0.248	1.416 (0.609–3.289)	0.419	0.899 (0.568–1.422)	0.649	1.961 (0.680–5.657)	0.213
FZD5
Low	Reference		Reference		Reference		Reference
High	1.001 (0.661–1.516)	0.996	2.061 (0.861–4.931)	0.104	0.886 (0.572–1.373)	0.59	1.107 (0.399–3.072)	0.845
FZD6
Low	Reference		Reference		Reference		Reference
High	1.680 (1.101–2.564)	0.016	6.159 (2.082–18.214)	0.001	1.951 (1.234–3.083)	0.004	9.299 (2.510–34.450)	0.001
FZD8
Low	Reference		Reference		Reference		Reference
High	0.600 (0.394–0.915)	0.018	1.257 (0.535–2.956)	0.599	0.659 (0.414–1.048)	0.078	1.634 (0.582–4.589)	0.351
FZD9
Low	Reference		Reference		Reference		Reference
High	0.764 (0.503–1.161)	0.207	0.555 (0.235–1.313)	0.180	0.878 (0.569–1.355)	0.556	0.704 (0.239–2.075)	0.525

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