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Table 1 Univariable and multivariable analysis of OS and RFS in patients with PAAD

From: Expression and prognostic impact of FZDs in pancreatic adenocarcinoma

Variables Univariable analysis Multivariable analysis
OS RFS OS RFS
HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
Age, years 1.027 (1.006–1.049) 0.012 1.024 (0.974–1.077) 0.355 1.028 (1.005–1.051) 0.018 1.027 (0.964–1.095) 0.409
Gender         
Male Reference   Reference   Reference   Reference  
Female 1.159 (0.768–1.750) 0.483 2.199 (0.924–5.236) 0.075 1.134 (0.729–1.764) 0.578 2.661 (0.916–7.729) 0.072
Grade         
I + II Reference   Reference   Reference   Reference  
III + IV 1.512 (0.979–2.335) 0.062 1.367 (0.561–3.331) 0.491 1.199 (0.754–1.908) 0.443 1.278 (0.437–3.739) 0.654
FZD3         
Low Reference   Reference   Reference   Reference  
High 0.647 (0.427–0.983) 0.041 0.705 (0.301–1.651) 0.421 0.639 (0.408–1.000) 0.048 0.323 (0.097–1.072) 0.065
FZD4         
Low Reference   Reference   Reference   Reference  
High 0.783 (0.518–1.185) 0.248 1.416 (0.609–3.289) 0.419 0.899 (0.568–1.422) 0.649 1.961 (0.680–5.657) 0.213
FZD5         
Low Reference   Reference   Reference   Reference  
High 1.001 (0.661–1.516) 0.996 2.061 (0.861–4.931) 0.104 0.886 (0.572–1.373) 0.59 1.107 (0.399–3.072) 0.845
FZD6         
Low Reference   Reference   Reference   Reference  
High 1.680 (1.101–2.564) 0.016 6.159 (2.082–18.214) 0.001 1.951 (1.234–3.083) 0.004 9.299 (2.510–34.450) 0.001
FZD8         
Low Reference   Reference   Reference   Reference  
High 0.600 (0.394–0.915) 0.018 1.257 (0.535–2.956) 0.599 0.659 (0.414–1.048) 0.078 1.634 (0.582–4.589) 0.351
FZD9         
Low Reference   Reference   Reference   Reference  
High 0.764 (0.503–1.161) 0.207 0.555 (0.235–1.313) 0.180 0.878 (0.569–1.355) 0.556 0.704 (0.239–2.075) 0.525