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Table 3 Contractile activity of mouse proximal colon during acute SCFAs application in IBS model group

From: Short chain fatty acids and colon motility in a mouse model of irritable bowel syndrome

Concentration of SCFAs (mM)

Tonic tension (g)

Amplitude (g)

Frequency (min−1)

Sodium acetate

   

 Initial value

0.879 ± 0.01

0.884 ± 0.058

3.204 ± 0.117

 0.5

0.85 ± 0.009

0.893 ± 0.024

2.694 ± 0.098*

 1

0.791 ± 0.009*

0.801 ± 0.026*

2.643 ± 0.097*

 5

0.864 ± 0.009*

0.783 ± 0.028*#

2.469 ± 0.121*

 10

0.723 ± 0.008*

0.693 ± 0.029*#

1.857 ± 0.092*#

 30

0.648 ± 0.007*

0.532 ± 0.034*#

1.143 ± 0.13*#

Sodium propionate

   

 Initial value

0.815 ± 0.021

0.848 ± 0.057

2.636 ± 0.102

 0.5

0.814 ± 0.021

0.901 ± 0.026

2.33 ± 0.096

 1

0.767 ± 0.02

0.795 ± 0.026

1.773 ± 0.08*

 5

0.727 ± 0.019*

0.77 ± 0.029

1.417 ± 0.087*

 10

0.698 ± 0.018*#

0.633 ± 0.027*#

1.045 ± 0.076*

 30

0.516 ± 0.019*#

0.58 ± 0.029*#

0.693 ± 0.098*#

Butyric acid

   

 Initial value

0.855 ± 0.023

0.857 ± 0.046

2.512 ± 0.086

 0.5

0.832 ± 0.021

0.873 ± 0.025

2.427 ± 0.107

 1

0.811 ± 0.02

0.787 ± 0.023#

1.878 ± 0.143*#

 5

0.757 ± 0.025

0.724 ± 0.026#

1.463 ± 0.105*#

 10

0.772 ± 0.018*#

0.652 ± 0.032*#

1.203 ± 0.133*#

 30

0.714 ± 0.021*#

0.501 ± 0.033*#

1.069 ± 0.147*#

  1. *p < 0.05 compared to the initial value; #p < 0.05 compared to the control group