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Table 2 Logistic regression analyses regarding the association of sociodemographic, work- and lifestyle-related factors with eALT (n = 14,732)

From: Factors associated with elevated alanine aminotransferase in employees of a German chemical company: results of a large cross-sectional study

 

Logistic regression (n = 14,732)

Univariable

Multivariable

OR (95%-CI)

aOR (95%-CI)

Sociodemographic factors

 Age (in years)

  < 35

Reference

Reference

  35–39

1.21 (1.05–1.40)

1.02 (0.88–1.20)

  40–44

1.12 (0.97–1.28)

0.88 (0.76–1.03)

  45–49

1.21 (1.06–1.37)

0.82 (0.71–0.94)

  50–54

1.14 (1.00–1.30)

0.67 (0.58–0.77)

   ≥ 55

1.08 (0.93–1.24)

0.58 (0.50–0.69)

 Gender

  Male

3.50 (3.04–4.03)

2.61 (2.24–3.05)

  Female

Reference

Reference

Work-related factors

 Working time system

  Day work

Reference

Reference

  Shift work

1.55 (1.42–1.69)

0.93 (0.84–1.04)

 Occupational group

  Manual worker

2.02 (1.80–2.28)

1.23 (1.06–1.43)

  Skilled/supervisory worker

1.31 (1.16–1.47)

1.07 (0.94–1.22)

  Managerial staff

Reference

Reference

Lifestyle-related factors

 Smoking status

  Non-smoker

Reference

Reference

  Former smoker

1.52 (1.38–1.68)

1.05 (0.94–1.18)

  Smoker

1.13 (1.01–1.26)

0.83 (0.74–0.94)

 Body-mass-index (kg/m2)

  Normal weight (< 25)

Reference

Reference

  Overweight (25– < 30)

3.05 (2.72–3.42)

2.66 (2.36–3.00)

  Obesity class I (30– < 35)

6.79 (5.95–7.74)

6.10 (5.29–7.02)

  Obesity class II (35– < 40)

8.45 (6.95–10.28)

7.75 (6.30–9.54)

  Obesity class III (≥ 40)

8.19 (6.07–11.06)

7.88 (5.75–10.80)

 Alcohol consumption (drinks per week)

  < 1

Reference

Reference

  1

1.15 (1.02–1.28)

1.21 (1.07–1.37)

  2

1.13 (1.01–1.28)

1.14 (1.00–1.30)

  ≥ 3

1.41 (1.25–1.58)

1.32 (1.16–1.49)

Diabetes

 History of diabetes mellitus

  No

Reference

Reference

  Yes

2.45 (2.06–2.91)

1.47 (1.22–1.78)

Time of examination

 Day of weeka

  Monday

Reference

b

  Tuesday

0.98 (0.87–1.12)

b

  Wednesday

1.00 (0.87–1.14)

b

  Thursday

1.02 (0.90–1.17)

b

  Friday

0.98 (0.85–1.13)

b

  Weekend

–

b

 Season

  Spring (March–May)

1.43 (1.27–1.62)

1.40 (1.23–1.59)

  Summer (June–August)

Reference

Reference

  Fall (September–November)

1.17 (1.02–1.33)

1.21 (1.06–1.40)

  Winter (December–February)

1.47 (1.31–1.66)

1.49 (1.31–1.69)

 Year

  2013

Reference

Reference

  2014

1.18 (1.05–1.33)

1.00 (0.88–1.14)

  2015

1.20 (1.02–1.40)

1.09 (0.92–1.28)

  2016

1.22 (1.06–1.40)

1.19 (1.02–1.38)

  2017

0.87 (0.76–1.01)

0.84 (0.72–0.98)

  2018

1.08 (0.95–1.23)

1.05 (0.91–1.20)

  1. (a)OR, (adjusted) odds ratio; 95%-CI, 95%-confidence interval
  2. aCategory "weekend" contained only two observations and was discarded when performing regression analyses
  3. bVariable not considered in multivariable logistic regression model