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Table 1 Prevalence of elevated ALT stratified by sociodemographic, work- and lifestyle-related factors (n = 15,348)

From: Factors associated with elevated alanine aminotransferase in employees of a German chemical company: results of a large cross-sectional study

 

n (%)

% ALT elevated men: > 45 U/L women: > 34 U/L

Geometric mean U/L (GSD)

Median U/L (IQR)

Total

15,348 (100.0)

18.5

28.9 (1.65)

28 (21–40)

Sociodemographic factors

 Age (in years)

  < 35

4030 (26.3)

17.2

27.1 (1.70)

26 (19–38)

  35–39

1818 (11.9)

19.8

28.9 (1.70)

28 (20–40)

  40–44

2200 (14.3)

18.5

28.2 (1.68)

28 (20–40)

  45–49

2742 (17.9)

19.5

30.1 (1.63)

29 (22–41)

  50–54

2534 (16.5)

18.9

30.6 (1.56)

30 (23–40)

  ≥ 55

2024 (13.2)

18.2

30.2 (1.57)

29 (22–39)

 Gender

  Male

12,013 (78.3)

21.6

32.8 (1.56)

31 (24–43)

  Female

3335 (21.7)

7.2

18.5 (1.52)

18 (14–23)

Work-related factors

 Working time system

  Day work

10,931 (71.2)

16.4

27.5 (1.66)

27 (19–38)

  Shift work

4417 (28.8)

23.6

32.9 (1.59)

32 (24–44)

 Occupational group

  Manual worker

5447 (35.5)

24.0

32.8 (1.61)

32 (24–44)

  Skilled/supervisory worker

6453 (42.0)

16.8

27.3 (1.67)

27 (19–38)

  Managerial staff

3448 (22.5)

13.1

26.5 (1.61)

26 (19–35)

Lifestyle-related factors

 Smoking statusa

  Non-smoker

8735 (56.9)

16.6

27.6 (1.65)

27 (20–38)

  Former smoker

3552 (23.1)

23.3

32.2 (1.62)

32 (23–44)

  Smoker

3023 (19.7)

18.6

29.5 (1.63)

29 (21–40)

 Body-mass-index (kg/m2)a

  Normal weight (< 25)

6138 (40.0)

7.8

23.1 (1.57)

23 (17–30)

  Overweight (25– < 30)

6281 (40.9)

20.1

31.5 (1.57)

31 (23–42)

  Obesity class I (30– < 35)

2150 (14.0)

36.4

38.0 (1.62)

38 (28–53)

  Obesity class II (35– < 40)

570 (3.7)

40.7

39.9 (1.71)

39.5 (28–56)

  Obesity class III (≥ 40)

207 (1.4)

40.1

40.5 (1.65)

37 (30–56)

 Alcohol consumptiona (drinks per week)

  < 1

4297 (28.0)

16.5

27.1 (1.67)

26 (19–37)

  1

3911 (25.5)

18.4

28.2 (1.66)

27 (20–39)

  2

3294 (21.5)

18.3

29.7 (1.61)

29 (22–40)

  ≥ 3

3256 (21.2)

21.7

31.9 (1.61)

31 (23–43)

Diabetes

 History of diabetes mellitus

  No

14,711 (95.9)

17.8

28.6 (1.64)

28 (21–39)

  Yes

637 (4.2)

35.5

37.4 (1.68)

36 (27–53)

Time of examination

 Day of week

  Monday

2920 (19.0)

18.5

28.6 (1.65)

28 (21–40)

  Tuesday

3717 (24.2)

18.5

28.7 (1.65)

28 (20–40)

  Wednesday

3170 (20.7)

18.6

29.1 (1.66)

28 (21–40)

  Thursday

3074 (20.0)

18.9

29.5 (1.62)

29 (21–39)

  Friday

2465 (16.1)

18.0

28.8 (1.66)

28 (20–39)

  Weekend

2 (0.0)

–

–

–

 Season

  Spring (March–May)

4175 (27.2)

20.2

29.9 (1.65)

29 (21–41)

  Summer (June–August)

3589 (23.4)

15.1

27.2 (1.63)

27 (20–37)

  Fall (September–November)

3291 (21.4)

17.2

28.4 (1.64)

28 (20–39)

  Winter (December–February)

4293 (28.0)

20.8

30.0 (1.66)

29 (21–41)

 Year

  2013

5778 (37.7)

17.6

28.4 (1.65)

28 (20–39)

  2014

2471 (16.1)

20.2

30.3 (1.63)

30 (22–41)

  2015

1232 (8.0)

20.6

29.7 (1.61)

29 (21–40)

  2016

1628 (10.6)

20.4

29.6 (1.68)

29 (21–40)

  2017

1897 (12.4)

15.5

27.8 (1.63)

27 (20–38)

  2018

2342 (15.3)

19.0

29.0 (1.67)

28 (21–39)

  1. GSD, geometric standard deviation factor, dimensionless, to be multiplied/divided by the geometric mean; IQR, interquartile range
  2. aMissing values for smoking status (n = 38), BMI (n = 2) and alcohol consumption (n = 590) have been omitted in the table