Faecal calprotectin is the biomarker that best distinguishes remission from different degrees of endoscopic activity in Crohn’s disease

Table 5 Sensitivity (Sens), specificity (Spec), positive predictive value (PPV), negative predictive value (NPV) and accuracy (A) for each biomarker and their respective cut-offs and 95% confidence intervals (95% CI) in the diagnosis of inflammatory activity in 80 patients with Crohn’s disease

	Sens	95% CI	Spec	95% CI	PPV	95% CI	NPV	95% CI	A	95% CI
fCal≥155 mcg/g	0.96	0.91–1.0	0.44	0.27–0.61	0.77	0.68–0.86	0.86	0.68–1.0	0.78	0.70–0.86
fCal≥199 mcg/g	0.90	0.83–0.97	0.48	0.31–0.65	0.77	0.68–0.86	0.72	0.53–0.90	0.76	0.67–0.84
fCal≥246 mcg/g	0.89	0.82–0.97	0.52	0.35–0.69	0.78	0.69–0.88	0.70	0.53–0.89	0.76	0.68–0.85
fCal≥273 mcg/g	0.87	0.79–0.95	0.56	0.39–0.73	0.79	0.70–0.88	0.68	0.52–0.86	0.76	0.68–0.85
fCal≥1009 mcg/g	0.52	0.40–0.64	0.85	0.73–0.97	0.87	0.77–0.98	0.48	0.35–0.60	0.63	0.54–0.85
fCal≥1473 mcg/g	0.40	0.28–0.52	0.93	0.84–1.0	0.91	0.82–1.0	0.44	0.33–0.56	0.58	0.48–0.68
PCR ≥ 6.7 mg/L	0.75	0.65–0.85	0.67	0.51–0.83	0.81	0.72–0.91	0.58	0.43–0.73	0.72	0.64–0.81
Plaq≥ 292,500/mm³	0.65	0.54–0.74	0.67	0.51–0.83	0.79	0.69–0.90	0.5	0.35–0.64	0.66	0.56–0.75

fCal Faecal calprotectin, CRP serum C-reactive protein, Platelets Platelet count, 95% CI 95% confidence interval, Sens Sensitivity, Spec Specificity, PPV Positive predictive value, NPV Negative predictive value, A Accuracy

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