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Table 3 Incidence rates and hazard ratios of non-alcoholic fatty liver disease according to sleep disorder status

From: Non-alcoholic fatty liver disease among patients with sleep disorders: a Nationwide study of Taiwan

 

Comparison Cohort

Sleep Disorder Cohort

Compared to the Comparison Cohort

Hazard Ratio (95% Confidence Interval)

Characteristics

Event

Person-year

IR

Event

Person-year

IR

Crude

p-value

Adjusteda

p-value

Sex

 Women

65

142,160

4.6

260

195,118

13.3

2.92 (2.22–3.83)

< 0.001

1.82 (1.35–2.46)

< 0.001

 Men

141

190,961

7.4

181

119,509

15.2

2.04 (1.64–2.54)

< 0.001

1.79 (1.38–2.32)

< 0.001

Age (year)

 20–39

88

183,841

4.8

78

76,805

10.2

2.11 (1.55–2.86)

< 0.001

1.71 (1.18–2.48)

0.004

 40–59

89

111,058

8.0

248

134,146

18.5

2.31 (1.81–2.94)

< 0.001

1.89 (1.44–2.47)

< 0.001

  ≥ 60

29

38,222

7.6

115

103,676

11.1

1.46 (0.97–2.20)

0.07

1.23 (0.79–1.91)

0.35

Comorbidities

 Diabetes

  No

186

320,194

5.8

370

272,633

13.6

2.34 (1.96–2.79)

< 0.001

1.84 (1.50–2.26)

< 0.001

  Yes

20

12,927

15.5

71

41,995

16.9

1.11 (0.68–1.82)

0.68

1.17 (0.68–1.99)

0.57

 Dyslipidemia

  No

153

309,909

4.9

258

234,156

11.0

2.24 (1.83–2.73)

< 0.001

2.10 (1.67–2.65)

< 0.001

  Yes

53

23,212

22.8

183

80,471

22.7

0.99 (0.74–1.36)

0.99

1.03 (0.74–1.44)

0.85

 Hypertension

  No

157

295,681

5.3

250

183,442

13.6

2.56 (2.10–3.13)

< 0.001

2.03 (1.61–2.57)

< 0.001

  Yes

49

37,440

13.1

191

131,186

14.6

1.12 (0.82–1.53)

0.49

1.09 (0.78–1.52)

0.61

 Ischemic heart disease

  No

190

319,112

6.0

339

241,780

14.0

2.35 (1.97–2.81)

< 0.001

1.88 (1.53–2.31)

< 0.001

  Yes

16

14,009

11.4

102

72,847

14.0

1.23 (0.73–2.09)

0.44

1.04 (0.60–1.82)

0.88

 Depression

  No

203

331,189

6.1

371

275,610.

13.5

2.19 (1.85–2.60)

< 0.001

1.81 (1.48–2.20)

< 0.001

  Yes

3

1932

15.5

70

39,017

17.9

1.16 (0.37–3.68)

0.80

0.99 (0.31–3.17)

0.98

 Anxiety

  No

191

322,595

5.9

246

191,432

12.9

2.17 (1.79–2.62)

< 0.001

1.82 (1.48–2.24)

< 0.001

  Yes

15

10,526

14.3

195

123,196

15.8

1.11 (0.66–1.88)

0.69

1.04 (0.61–1.77)

0.88

  1. IR Incidence rate per 10,000 person-year
  2. aModel mutually adjusted for sex, age (categorical), diabetes, dyslipidemia, hypertension, depression, anxiety, and ischemic heart disease