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Table 3 Incidence rates and hazard ratios of non-alcoholic fatty liver disease according to sleep disorder status

From: Non-alcoholic fatty liver disease among patients with sleep disorders: a Nationwide study of Taiwan

 Comparison CohortSleep Disorder CohortCompared to the Comparison Cohort
Hazard Ratio (95% Confidence Interval)
CharacteristicsEventPerson-yearIREventPerson-yearIRCrudep-valueAdjustedap-value
Sex
 Women65142,1604.6260195,11813.32.92 (2.22–3.83)< 0.0011.82 (1.35–2.46)< 0.001
 Men141190,9617.4181119,50915.22.04 (1.64–2.54)< 0.0011.79 (1.38–2.32)< 0.001
Age (year)
 20–3988183,8414.87876,80510.22.11 (1.55–2.86)< 0.0011.71 (1.18–2.48)0.004
 40–5989111,0588.0248134,14618.52.31 (1.81–2.94)< 0.0011.89 (1.44–2.47)< 0.001
  ≥ 602938,2227.6115103,67611.11.46 (0.97–2.20)0.071.23 (0.79–1.91)0.35
Comorbidities
 Diabetes
  No186320,1945.8370272,63313.62.34 (1.96–2.79)< 0.0011.84 (1.50–2.26)< 0.001
  Yes2012,92715.57141,99516.91.11 (0.68–1.82)0.681.17 (0.68–1.99)0.57
 Dyslipidemia
  No153309,9094.9258234,15611.02.24 (1.83–2.73)< 0.0012.10 (1.67–2.65)< 0.001
  Yes5323,21222.818380,47122.70.99 (0.74–1.36)0.991.03 (0.74–1.44)0.85
 Hypertension
  No157295,6815.3250183,44213.62.56 (2.10–3.13)< 0.0012.03 (1.61–2.57)< 0.001
  Yes4937,44013.1191131,18614.61.12 (0.82–1.53)0.491.09 (0.78–1.52)0.61
 Ischemic heart disease
  No190319,1126.0339241,78014.02.35 (1.97–2.81)< 0.0011.88 (1.53–2.31)< 0.001
  Yes1614,00911.410272,84714.01.23 (0.73–2.09)0.441.04 (0.60–1.82)0.88
 Depression
  No203331,1896.1371275,610.13.52.19 (1.85–2.60)< 0.0011.81 (1.48–2.20)< 0.001
  Yes3193215.57039,01717.91.16 (0.37–3.68)0.800.99 (0.31–3.17)0.98
 Anxiety
  No191322,5955.9246191,43212.92.17 (1.79–2.62)< 0.0011.82 (1.48–2.24)< 0.001
  Yes1510,52614.3195123,19615.81.11 (0.66–1.88)0.691.04 (0.61–1.77)0.88
  1. IR Incidence rate per 10,000 person-year
  2. aModel mutually adjusted for sex, age (categorical), diabetes, dyslipidemia, hypertension, depression, anxiety, and ischemic heart disease