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Table 3 Stratified analysis and effects of cirrhosis-related clinical indicators on 30-day mortality of ICU patients

From: A population-based cohort study of mortality of intensive care unit patients with liver cirrhosis

 

n

30-day mortality

Deaths

Mortality, %

OR

(95% CI)a

Pre-ICU characteristics within 2 years

 No LC

37,197

4046

10.9

1.00

(reference)

 LC without liver cancer

25,758

3705

14.4

1.48

(1.41 to 1.56)

 LC with liver cancer

11,439

2190

19.2

1.85

(1.74 to 1.97)

 LC with no HBV and HCV

22,258

3366

15.1

1.55

(1.47 to 1.63)

 LC with HBV or HCV

13,573

2288

16.9

1.67

(1.58 to 1.77)

 LC with HBV and HCV

1366

241

17.6

1.75

(1.50 to 2.03)

 LC without ADS

34,496

5450

15.8

1.59

(1.52 to 1.66)

 LC with ADS

2701

445

16.5

1.82

(1.62 to 2.04)

 LC without jaundice

33,978

5171

15.2

1.54

(1.47 to 1.62)

 LC with jaundice

3219

724

22.5

2.23

(2.03 to 2.45)

 LC without ascites

26,352

3332

12.6

1.30

(1.23 to 1.37)

 LC with ascites

10,845

2563

23.6

2.32

(2.19 to 2.46)

 LC without GI hemorrhage

27,652

4114

14.9

1.50

(1.43 to 1.58)

 LC with GI hemorrhage

9545

1781

18.7

1.90

(1.78 to 2.03)

 LC without hepatic coma

29,252

4102

14.0

1.43

(1.37 to 1.37)

 LC with hepatic coma

7945

1793

22.6

2.21

(2.07 to 2.36)

 LC with 0 admission

25,677

3378

13.2

1.33

(1.26 to 1.40)

 LC with 1 admission

6600

1411

21.4

2.16

(2.01 to 2.32)

 LC with 2 admissions

2449

521

21.3

2.14

(1.92 to 2.38)

 LC with 3 admissions

1059

248

23.4

2.37

(2.03 to 2.76)

 LC with ≥4 admissions

1412

337

23.9

2.52

(2.20 to 2.89)

 LC with 0 days of hospital stay

25,677

3378

13.2

1.33

(1.26 to 1.40)

 LC with 1–9 days of hospital stay

5144

996

19.4

1.92

(1.77 to 2.08)

 LC with 10–19 days of hospital stay

3022

664

22.0

2.23

(2.02 to 2.45)

 LC with 20–29 days of hospital stay

1312

305

23.3

2.30

(2.00 to 2.65)

 LC with ≥30 days of hospital stay

2042

552

27.0

2.97

(2.66 to 3.31)

 LC without albumin supplement

23,279

3140

13.5

1.40

(1.33 to 1.47)

 LC with albumin supplement

13,918

2755

19.8

1.93

(1.83 to 2.04)

 LC without alcohol-related illness

24,894

3581

14.4

1.25

(1.20 to 1.31)

 LC with alcohol-related illness

12,303

2314

18.8

1.75

(1.66 to 1.85)

 LC without hospitalizations

7214

756

10.5

0.91

(0.84 to 0.98)

 LC with hospitalizations

29,983

5139

17.1

1.52

(1.46 to 1.58)

Reasons for ICU admission

 Digestive disease, no LC

10,198

550

5.4

1.00

(reference)

 Digestive disease, LC

10,198

1511

14.8

3.23

(2.91 to 3.58)

 Cancer, no LC

6726

1031

15.3

1.00

(reference)

 Cancer, LC

6726

1154

17.2

1.15

(1.05 to 1.27)

 Respiratory disease, no LC

4524

837

18.5

1.00

(reference)

 Respiratory disease, LC

4524

986

21.8

1.24

(1.12 to 1.38)

 Circulatory disease, no LC

4385

384

8.8

1.00

(reference)

 Circulatory disease, LC

4385

530

12.1

1.47

(1.28 to 1.70)

 Infectious disease, no LC

3518

807

22.9

1.00

(reference)

 Infectious disease, LC

3518

983

27.9

1.32

(1.19 to 1.48)

 Injury and poisoning, no LC

2918

192

6.6

1.00

(reference)

 Injury and poisoning, LC

2918

345

11.8

1.95

(1.61 to 2.35)

 Symptom-defined conditions, no LC

862

123

14.3

1.00

(reference)

 Symptom-defined conditions, LC

862

194

22.5

1.86

(1.43 to 2.42)

 Genitourinary disease, no LC

762

38

5.0

1.00

(reference)

 Genitourinary disease, LC

762

59

7.7

1.74

(1.10 to 2.75)

 Endocrine disease, no LC

605

24

4.0

1.00

(reference)

 Endocrine disease, LC

605

31

5.1

1.36

(0.76 to 2.43)

 Musculoskeletal disease, no LC

598

17

2.8

1.00

(reference)

 Musculoskeletal disease, LC

598

42

7.0

3.49

(1.79 to 6.82)

 Mental disorder, no LC

278

0

0.0

1.00

(reference)

 Mental disorder, LC

278

0

0.0

–

–

 Neurological disease, no LC

304

11

3.6

1.00

(reference)

 Neurological disease, LC

304

25

8.2

2.94

(1.30 to 6.65)

 Skin disease, no LC

291

7

2.4

1.00

(reference)

 Skin disease, LC

291

8

2.8

1.23

(0.35 to 4.39)

 Tumor, no LC

254

2

0.8

1.00

(reference)

 Tumor, LC

254

5

2.0

3.33

(0.51 to 21.8)

 Blood disease, no LC

76

5

6.6

1.00

(reference)

 Blood disease, LC

76

3

4.0

0.38

(0.05 to 2.84)

 Congenital anomalies, no LC

40

1

2.5

1.00

(reference)

 Congenital anomalies, LC

40

0

0.0

–

–

 Disease of perinatal period, no LC

33

1

3.0

1.00

(reference)

 Disease of perinatal period, LC

33

0

0.0

–

–

 Complications of pregnancy, no LC

7

0

0.0

1.00

(reference)

 Complications of pregnancy, LC

7

1

14.3

–

–

 0 CCI score, no LC

10,476

1066

10.2

1.00

(reference)

 0 CCI score, LC

1165

101

8.7

0.97

(0.77 to 1.23)

 1 CCI score, no LC

8899

731

8.2

1.00

(reference)

 1 CCI score, LC

6656

818

12.3

1.38

(1.21 to 1.58)

 2 CCI score, no LC

6573

592

9.0

1.00

(reference)

 2 CCI score, LC

5116

592

11.6

1.49

(1.31 to 1.70)

 3 CCI score, no LC

3897

355

9.1

1.00

(reference)

 3 CCI score, LC

5478

760

13.9

1.45

(1.25 to 1.69)

 4 CCI score, no LC

1823

209

11.5

1.00

(reference)

 4 CCI score, LC

7085

1325

18.7

1.40

(1.17 to 1.67)

  ≥ 5 CCI score, no LC

5529

1093

19.8

1.00

(reference)

  ≥ 5 CCI score, LC

11,697

2299

19.7

1.08

(0.99 to 1.18)

  1. ADS alcohol dependence syndrome, CI confidence interval, GI gastrointestinal, HBV hepatitis B virus, HCV hepatitis C virus, ICU intensive care unit, LC liver cirrhosis, OR odds ratio
  2. aAdjusted all covariates listed in Table 1