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Fig. 4 | BMC Gastroenterology

Fig. 4

From: A rare case of Epstein–Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report

Fig. 4

Histopathological analysis. Histopathological analysis revealed widespread erosion of the mucosa and the formation of granulation tissue with marked infiltration of inflammatory cells consisting of small lymphocytes, plasma cells, histiocytes, and medium-size atypical nucleated cells in the mucosal tissue of the large intestine (hematoxylin–eosin stain, original magnification × 40) (a). Some of the CD20-positive B cells identified by immunohistochemical analysis (original magnification × 40) (b) were also found to be positive for EBER-1 by ISH (original magnification × 40) (c). The resected specimen showed an ulcerative lesion with narrowing of the lumen (d). The histopathological analysis of the resected specimen revealed marked infiltration of inflammatory cells, consisting mainly of small lymphocytes and plasma cells, as well as fibrosis in all layers of the colon wall (hematoxylin–eosin stain, original magnification × 2) (e). HRS-like multinucleated large B cells were also occasionally present (hematoxylin–eosin stain, original magnification × 40) (f)

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