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Table 3 Incidence rates, hazard ratios, and confidence intervals of HCC among different stratifications of HCV patients with and without aspirin use

From: Aspirin decreases hepatocellular carcinoma risk in hepatitis C virus carriers: a nationwide cohort study

VariablesAspirinAspirin VS. Non-aspirin
No
(n = 1911)
Yes
(n = 1911)
Crude HR
(95% CI)
Adjusted HR
(95% CI)
EventPerson yearsIREventPerson yearsIR
Overall14768482.1513185461.530.73(0.58–0.93)**0.56(0.43–0.72)***
Gender
 Female6638381.725747071.210.72(0.51–1.03)0.51(0.35–0.76)***
 Male8130102.697438391.930.72(0.53–0.99)*0.59(0.42–0.83)**
Age, years
  < 400592026330.32  
 40–593129291.062730690.880.83(0.5–1.39)0.64(0.35–1.14)
 60–799828883.399443252.170.65(0.49–0.87)**0.56(0.41–0.76)***
  ≥ 80184404.0985181.540.44(0.19–1.01)0.45(0.18–1.11)
Baseline comorbidity
 Hypertension
  No3917132.283125571.210.55(0.34–0.88)*0.39(0.23–0.65)***
  Yes10851352.110059891.670.81(0.62–1.06)0.63(0.47–0.85)**
 Diabetes mellitus
  No9036922.447950601.560.65(0.48–0.88)**0.49(0.35–0.68)***
  Yes5731561.815234861.490.85(0.58–1.24)0.68(0.45–1.03)
 Moderate or severe liver disease
  No14567112.1613084681.540.73(0.57–0.92)**0.56(0.43–0.73)***
  Yes21371.461781.280.8(0.07–8.85) 
 Myocardial infarction
  No14364432.2212680571.560.72(0.57–0.92)**0.55(0.42–0.72)***
  Yes44050.9954891.021.02(0.27–3.82)0.72(0.16–3.23)
 Congestive heart failure
  No12754432.3310369691.480.65(0.5–0.84)**0.52(0.39–0.69)***
  Yes2014061.422815771.781.25(0.7–2.23)0.79(0.42–1.5)
 Ischemic stroke
  No6627542.46038581.560.66(0.46–0.93)*0.48(0.33–0.71)***
  Yes8140941.987146881.510.79(0.58–1.09)0.62(0.43–0.88)**
Drugs
 Anti-hypertensive agents
  No5643331.291921890.870.69(0.41–1.16)0.58(0.33–1.01)
  Yes9125153.6211263571.760.51(0.38–0.67)***0.53(0.4–0.71)***
 Hypoglycemic agents
  No14165482.1512480561.540.73(0.57–0.93)*0.55(0.42–0.72)***
  Yes6300274901.430.65(0.21–2.03)0.71(0.2–2.52)
 Coumadin and heparin
  No14567652.1412680371.570.75(0.59–0.95)*0.56(0.43–0.73)***
  Yes2832.455090.980.4(0.07–2.19)0.41(0.05–3.18)
 Other antithrombotic agents
  No13665312.089667031.430.71(0.54–0.92)**0.53(0.4–0.7)***
  Yes113183.463518431.90.56(0.29–1.12)0.68(0.34–1.37)
 NSAIDs
  No6935351.956531082.091.07(0.76–1.5)0.79(0.54–1.14)
  Yes7833132.356654371.210.54(0.39–0.74)***0.41(0.29–0.59)***
  1. Abbreviations: IR† Incidence rates, per 100 person-years, HR Hazard ratio, CI Confidence interval, NSAIDs Non-steroidal anti-inflammatory drugs
  2. * p < 0.05, ** p < 0.01, *** p < 0.001
  3. Adjusted HR: adjusted for gender, age, hypertension, diabetes mellitus, moderate or severe liver disease, myocardial infarction, congestive heart failure, ischemic stroke, anti-hypertension agents, hypoglycemic agents, coumadin and heparin, other antithrombotic agents and NSAIDs in Cox proportional hazards regression