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Table 3 Univariate and multivariable analysis of prognostic factors for overall survival in CC

From: DSG2 expression is low in colon cancer and correlates with poor survival

 

Univariate analysis

Multivariate analysis

P-value

95%CI

HR

P-value

95% CI

HR

Dsg2 expression

      

 Low or no

Reference

     

 High

0.996

< 0.001*

0.995–0.998

0.996

< 0.001*

0.995–0.998

Age(year)

      

 ≤ 60

Reference

     

 > 60

1.042

0.708

0.841–1.290

   

Gender

      

 Male

Reference

     

 Female

1.119

0.102

0.992–1.149

   

Location

      

 Right/Transverse

Reference

     

 Left/Sigmoid

1.004

0.919

0.922–1.094

   

Histological type

      

 Adenocarcinoma

Reference

     

 Mucinous/SRCCa

0.963

0.790

0.731–1.269

   

Differentiation

      

 Well/Moderate

Reference

     

 Poor/Othersb

1.202

0.056

0.947–1.380

   

Tumor size

      

 T1/T2

Reference

     

 T3/T4

1.295

< 0.001*

1.144–1.465

1.164

0.078

0.917–1.332

Lymph node metastasis

      

 N0/N1

Reference

     

 N2

0.642

 < 0.001*

0.549–0.750

0.931

0.081

0.846–1.633

Distant metastasis

      

 M0

Reference

     

 M1

3.098

 < 0.001*

2.421–3.965

3.245

 < 0.001*

2.462–4.276

AJCC stage

      

 I/II

Reference

     

 III/IV

1.331

 < 0.001*

1.186–1.495

1.254

0.002*

1.09–1.442

Venous invasion

      

 Negative

Reference

     

 Positive

2.735

 < 0.001*

2.145–3.486

2.815

 < 0.001*

2.175–3.644

Perineural invasion

      

 Negative

Reference

     

 Positive

1.481

0.075

0.951–1.730

   

CEA(ng/ml)

      

 ≤ 5

Reference

     

 > 5

1.031

0.781

0.833–1.275

   

CA199(ng/ml)

      

 ≤ 37

Reference

     

 > 37

0.950

0.634

0.768–1.175

   

Ki67

      

 Negative

Reference

     

 Positive

0.995

0.965

0.805–1.230

   
  1. Dsg2 expression, tumor size, lymph node metastasis, Distant metastasis, AJCC stage and venous invasion were included for multivariate analysis
  2. *P < 0.05, statistically significant
  3. aMucinous carcinoma is 57 cases; SRCC (signet-ring cell carcinoma) is 8 cases
  4. bNo clear differentiation stage record
  5. HR hazard ratio, CI confidence interval
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BMC Gastroenterology

ISSN: 1471-230X

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