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Table 1 Literature review of characteristics of PDAC patients with brain metastasis

From: Simultaneous brain and lung metastases of pancreatic ductal adenocarcinoma after curative pancreatectomy: a case report and literature review

First author ref yo, sex Operation Metastatic site Period between BM Dx to
PDAC Dx
Treatment to BM OS from BM Dx Molecular profiles
Kuratsu [17] 56yo, M
58yo, M
PD
(-)
(-)
Liver (S)
12 M
5 M
Ommaya + RT
Res
Dead (9 M)
Dead (2 W)
(-)
Chiang [18] 54yo, M (-) Liver (S) S Res + RT Alive (> 20 M) CK7( +), CK20(-)
TTF-1(-), CDX2(-)
MUC1/5AC( +), MUC2(-)
KRASG12Vmutation
Caricato [19] 54yo, M PD (-) 24 M Res Alive (> 12 M) (-)
Park [20] 48yo, M
51yo, M
52yo, M
62yo, M
(-) Lung (S)
Lung, Liver, Bone (S)
Liver (S)
Lung (S)
4 M
S
5 M
S
RT
BSC
RT
BSC
MST 2.9 M
(1.5 M-3.8 M)
(-)
El Kamar [4] 56yo, M (-) Liver (S) 6 M chemoTX Dead (3D) CK7( +), CK20( +)
TTF-1(-)
Lemke [21] 48yo, F
66yo, M
DP
DP
Liver (36 M)
(-)
72 M
12 M
Res + RT
Res + RT
Alive (> 10Y)
Alive (> 6Y)
(-)
Matsumura [22] 64yo, M DP LN (12 M) 14 M Res + RT Alive (> 10 M) (-)
Marepaily [23] 36yo, F (-) Liver (S) 12 M Res Dead (< 1 M) Adnab-9
Matsumoto [24] 68yo, M (-) Liver (S) S Res Dead (3 M) CK7( +), CK20(-)
Rajappa [25] 67yo, M (-) Liver (S), Lung (52 M) 48 M Res + RT Dead (36 M) CK7( +), CK19( +)
TTF-1(-)
Zaanan [26] 57yo, M PD Liver (6 M) 48 M BSC Dead (3D) (-)
Rao [27] 58yo, M (-) Lung, Liver,
Bone (S)
S RT Dead (< 3 M) CK7( +), CEA( +)
CK20/CDX2/
TTF-1(-)
Kumar [8] Median
61.5yo
(N = 8)
PD (n = 5)
DP (n = 1)
Partial (n = 1)
(-) (n = 1)
Lung (n = 3)
Liver (n = 2)
Bone (n = 3)
LN (n = 3)
Median period 29 M
(2 M-57 M)
Reported
(n = 4):
Res + RT
(n = 1)
Res (n = 1)
RT (n = 2)
 > 9Y
(post Res)
(-)
Matsuo [28] 61yo, F (-) Ascites (S) 16 M Res Dead (3 W) (-)
Sasaki [9] 72yo, F
78yo, M
(-)
DP
Liver (S)
Lung (5 M)
19 M
28 M
RT
RT
Dead (13 M)
Dead (32D)
(-)
Our case 69yo, M DP Lung (8 M) 8 M Ommaya
 + γknife
Alive (> 1 M) CAIX( +)
MUC1/5AC( +)
CDX2/MUC2( +)
  1. BM: Brain metastasis, BSC: best supportive care, D: days, DP: distal pancreatosplenectomy, Dx: diagnosis, LN: lymph node, M: months, MST: median survival time, N: no, Res: resection, OS: overall survival time, PD: pancreaticoduodenectomy, RT: radiotherapy, S: synchronous, Tx: therapy, Y: years, Y: Yes, yo: years old