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Table 1 Literature review of characteristics of PDAC patients with brain metastasis

From: Simultaneous brain and lung metastases of pancreatic ductal adenocarcinoma after curative pancreatectomy: a case report and literature review

First author ref

yo, sex

Operation

Metastatic site

Period between BM Dx to

PDAC Dx

Treatment to BM

OS from BM Dx

Molecular profiles

Kuratsu [17]

56yo, M

58yo, M

PD

(-)

(-)

Liver (S)

12 M

5 M

Ommaya + RT

Res

Dead (9 M)

Dead (2 W)

(-)

Chiang [18]

54yo, M

(-)

Liver (S)

S

Res + RT

Alive (> 20 M)

CK7( +), CK20(-)

TTF-1(-), CDX2(-)

MUC1/5AC( +), MUC2(-)

KRASG12Vmutation

Caricato [19]

54yo, M

PD

(-)

24 M

Res

Alive (> 12 M)

(-)

Park [20]

48yo, M

51yo, M

52yo, M

62yo, M

(-)

Lung (S)

Lung, Liver, Bone (S)

Liver (S)

Lung (S)

4 M

S

5 M

S

RT

BSC

RT

BSC

MST 2.9 M

(1.5 M-3.8 M)

(-)

El Kamar [4]

56yo, M

(-)

Liver (S)

6 M

chemoTX

Dead (3D)

CK7( +), CK20( +)

TTF-1(-)

Lemke [21]

48yo, F

66yo, M

DP

DP

Liver (36 M)

(-)

72 M

12 M

Res + RT

Res + RT

Alive (> 10Y)

Alive (> 6Y)

(-)

Matsumura [22]

64yo, M

DP

LN (12 M)

14 M

Res + RT

Alive (> 10 M)

(-)

Marepaily [23]

36yo, F

(-)

Liver (S)

12 M

Res

Dead (< 1 M)

Adnab-9

Matsumoto [24]

68yo, M

(-)

Liver (S)

S

Res

Dead (3 M)

CK7( +), CK20(-)

Rajappa [25]

67yo, M

(-)

Liver (S), Lung (52 M)

48 M

Res + RT

Dead (36 M)

CK7( +), CK19( +)

TTF-1(-)

Zaanan [26]

57yo, M

PD

Liver (6 M)

48 M

BSC

Dead (3D)

(-)

Rao [27]

58yo, M

(-)

Lung, Liver,

Bone (S)

S

RT

Dead (< 3 M)

CK7( +), CEA( +)

CK20/CDX2/

TTF-1(-)

Kumar [8]

Median

61.5yo

(N = 8)

PD (n = 5)

DP (n = 1)

Partial (n = 1)

(-) (n = 1)

Lung (n = 3)

Liver (n = 2)

Bone (n = 3)

LN (n = 3)

Median period 29 M

(2 M-57 M)

Reported

(n = 4):

Res + RT

(n = 1)

Res (n = 1)

RT (n = 2)

 > 9Y

(post Res)

(-)

Matsuo [28]

61yo, F

(-)

Ascites (S)

16 M

Res

Dead (3 W)

(-)

Sasaki [9]

72yo, F

78yo, M

(-)

DP

Liver (S)

Lung (5 M)

19 M

28 M

RT

RT

Dead (13 M)

Dead (32D)

(-)

Our case

69yo, M

DP

Lung (8 M)

8 M

Ommaya

 + γknife

Alive (> 1 M)

CAIX( +)

MUC1/5AC( +)

CDX2/MUC2( +)

  1. BM: Brain metastasis, BSC: best supportive care, D: days, DP: distal pancreatosplenectomy, Dx: diagnosis, LN: lymph node, M: months, MST: median survival time, N: no, Res: resection, OS: overall survival time, PD: pancreaticoduodenectomy, RT: radiotherapy, S: synchronous, Tx: therapy, Y: years, Y: Yes, yo: years old