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Table 7 Chracteristics of the included studies of 5-HT in this meta-analysis

From: Alterations in short-chain fatty acids and serotonin in irritable bowel syndrome: a systematic review and meta-analysis

References

Year

Location

n, IBS

n, Control

IBS diagnosis

Control

Composition

Age, IBS

(range, \({\overline{\text{x}}} + {\text{s}}\))

Female

IBS, n

Age, HC

(range, \({\overline{\text{x}}} + {\text{s}}\))

Female

HC, n

Sample

Technique

Yu et al. [30]

2016

China

30

30

Not reported

Healthy controls

39 ± 21

14

42.5 ± 19.5

15

Serum

HPLC

Dunlop et al. [31]

2005

Britain

15

15

Rome II

Healthy controls

35.1 ± 2.9

15

35.9 ± 2.6

10

Plasma

HPLC

Thijssen et al. [32]

2015

Netherlands

154

137

Rome III

Healthy controls

44.5 ± 16.3

108

44.2 ± 19.3

84

Plasma

HPLC

Park et al. [29]

2009

Korea

21

13

Rome II

Healthy controls

24–78

13

29–68

6

Plasma

HPLC

Keszthelyi et al. [33]

2013

Netherlands

15

15

Rome III

Healthy controls

44 ± 13

8

33 ± 17

10

Plasma

HPLC

  1. 5-HT, 5-hydroxytryptamine; IBS, irritable bowel syndrome; HC, healthy control; HPLC, high-pressure liquid chromatography