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Table 2 Analysis of the association between clinical characteristics and OS

From: Changes and prognostic impact of inflammatory nutritional factors during neoadjuvant chemoradiotherapy for patients with resectable and borderline resectable pancreatic cancer

 

Cutoff value

Univariate analysis

Multivariate analysis

Hazard ratio

p value

Hazard ratio

p value

Age (years)

≧ 70

1.1455

0.7395

  

Sex

Female

1.4304

0.3828

  

Location

Head

0.8938

0.8142

  

Resectability

BR-A or BR-PV

3.9383

0.0033

0.9127

0.8896

<Pre-NACRT>

 Tumor size (mm)

≧ 20

1.6170

0.3436

  

 CEA (ng/mL)

≧ 5.8

0.9582

0.9289

  

 CA19-9 (U/mL)

≧ 993

1.6661

0.2444

  

 FDG-PET (SUVmax)

≧ 10.87

0.9028

0.8294

  

 NLR

≧ 2.79

2.2490

0.0583

  

 Alb (g/dL)

≦ 3.5

0.9777

0.9624

  

 GPS

2 or 1

1.3676

0.4946

  

 mGPS

2 or 1

4.7085

0.007

3.8635

0.0478

 CRP/Alb ratio

≧ 0.124

2.2201

0.0738

  

<Post-NACRT>

 CEA (ng/mL)

≧ 6.5

1.0509

0.1986

  

 CA19-9 (U/mL)

≧ 483

1.1494

0.7716

  

 NLR

≧ 4.30

1.9694

0.1229

  

 Alb (g/dL)

≦ 3.2

2.1969

0.0665

  

 GPS

2 or 1

1.9590

0.1087

  

 mGPS

2 or 1

2.3647

0.0603

  

 CRP/Alb ratio

≧ 0.24

2.9130

0.00122

  

<Change of inflammatory response factor after NACRT>

 Î”: Post-NACRT-pre-NACRT

  Î”NLR

1.79

0.9952

0.9971

  

  GPS

Increase

2.2562

0.0583

  

  mGPS

Increase

2.3647

0.0603

  

  Î”CRP/Alb ratio

0.0769

3.2706

0.0060

5.1842

0.0036

<Perioperative factor>

 Operative time (min)

≧ 560

1.8544

0.1999

  

 Intraoperative bleeding (mL)

≧ 2088

2.4717

0.0387

1.1879

0.7548

 Complication after surgery

≧ IIIa

0.6719

0.4338

  

 Postoperative hospital stays (days)

≧ 43

0.7421

0.5302

  

 Adjuvant therapy

In-completion

1.9714

0.0990

  

<Pathological factor>

 Tumor size

≧ 20

2.8865

0.1536

  

 T

T3

1.4130

0.5319

  

 Differentiation

Moderate or poor

1.6448

0.2581

  

 Lymph node metastasis

N2 or N1

3.5747

0.0080

4.7976

0.0117

 ly

2 or 3

1.3131

0.59647

  

 v

2 or 3

1.7984

0.1657

  

 ne

2 or 3

1.4089

0.4079

  

 PV

1

5.6948

0.0001

2.6003

0.1012

 Surgical margins

R1

12.1127

0.0042

12.6514

0.0295

 Evans

I or IIa

2.1983

0.1255

  
  1. BR-A, borderline resectable with arterial invasion; BR-PV, borderline resectable with portal vein invasion; NACRT, neoadjuvant chemoradiotherapy; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; FDG-PET, fluorodeoxyglucose positron emission tomography; SUVmax, maximum standardized uptake value; NLR, neutrophil/lymphocyte ratio; Alb, albumin; GPS, Glasgow Prognostic Score; mGPS, modified Glasgow Prognostic Score; CRP, C-reactive protein; PV, portal vein