Cutoff value | Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|---|
Hazard ratio | p value | Hazard ratio | p value | ||
Age (years) | ≧ 70 | 1.1455 | 0.7395 | ||
Sex | Female | 1.4304 | 0.3828 | ||
Location | Head | 0.8938 | 0.8142 | ||
Resectability | BR-A or BR-PV | 3.9383 | 0.0033 | 0.9127 | 0.8896 |
<Pre-NACRT> | |||||
Tumor size (mm) | ≧ 20 | 1.6170 | 0.3436 | ||
CEA (ng/mL) | ≧ 5.8 | 0.9582 | 0.9289 | ||
CA19-9 (U/mL) | ≧ 993 | 1.6661 | 0.2444 | ||
FDG-PET (SUVmax) | ≧ 10.87 | 0.9028 | 0.8294 | ||
NLR | ≧ 2.79 | 2.2490 | 0.0583 | ||
Alb (g/dL) | ≦ 3.5 | 0.9777 | 0.9624 | ||
GPS | 2 or 1 | 1.3676 | 0.4946 | ||
mGPS | 2 or 1 | 4.7085 | 0.007 | 3.8635 | 0.0478 |
CRP/Alb ratio | ≧ 0.124 | 2.2201 | 0.0738 | ||
<Post-NACRT> | |||||
CEA (ng/mL) | ≧ 6.5 | 1.0509 | 0.1986 | ||
CA19-9 (U/mL) | ≧ 483 | 1.1494 | 0.7716 | ||
NLR | ≧ 4.30 | 1.9694 | 0.1229 | ||
Alb (g/dL) | ≦ 3.2 | 2.1969 | 0.0665 | ||
GPS | 2 or 1 | 1.9590 | 0.1087 | ||
mGPS | 2 or 1 | 2.3647 | 0.0603 | ||
CRP/Alb ratio | ≧ 0.24 | 2.9130 | 0.00122 | ||
<Change of inflammatory response factor after NACRT> | |||||
Δ: Post-NACRT-pre-NACRT | |||||
ΔNLR | 1.79 | 0.9952 | 0.9971 | ||
GPS | Increase | 2.2562 | 0.0583 | ||
mGPS | Increase | 2.3647 | 0.0603 | ||
ΔCRP/Alb ratio | 0.0769 | 3.2706 | 0.0060 | 5.1842 | 0.0036 |
<Perioperative factor> | |||||
Operative time (min) | ≧ 560 | 1.8544 | 0.1999 | ||
Intraoperative bleeding (mL) | ≧ 2088 | 2.4717 | 0.0387 | 1.1879 | 0.7548 |
Complication after surgery | ≧ IIIa | 0.6719 | 0.4338 | ||
Postoperative hospital stays (days) | ≧ 43 | 0.7421 | 0.5302 | ||
Adjuvant therapy | In-completion | 1.9714 | 0.0990 | ||
<Pathological factor> | |||||
Tumor size | ≧ 20 | 2.8865 | 0.1536 | ||
T | T3 | 1.4130 | 0.5319 | ||
Differentiation | Moderate or poor | 1.6448 | 0.2581 | ||
Lymph node metastasis | N2 or N1 | 3.5747 | 0.0080 | 4.7976 | 0.0117 |
ly | 2 or 3 | 1.3131 | 0.59647 | ||
v | 2 or 3 | 1.7984 | 0.1657 | ||
ne | 2 or 3 | 1.4089 | 0.4079 | ||
PV | 1 | 5.6948 | 0.0001 | 2.6003 | 0.1012 |
Surgical margins | R1 | 12.1127 | 0.0042 | 12.6514 | 0.0295 |
Evans | I or IIa | 2.1983 | 0.1255 |