Prognostic value of Glypican family genes in early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy and possible mechanisms

Table 2 Stratified analysis of Glypican genes in The Cancer Genome Atlas database

	GPC2				GPC3				GPC5
	Low	High	Adjusted HR 95% CI	Adjusted P 95%CI ^a	Low	High	Adjusted HR 95% CI	Adjusted P 95%CI ^a	Low	High	Adjusted HR 95% CI	Adjusted P 95%CI ^a
Age years)
≤60	16	22	0.433 (0.119–1.569)	0.202	20	18	1.061 (0.238–4.729)	0.938	18	20	0.197 (0.041–0.951)	0.043
> 60	40	34	0.415 (0.218–0.790)	0.007	36	38	0.517 (0.280–0.954)	0.035	38	36	0.637 (0.342–1.185)	0.154
Sex
Female	30	23	0.481 (0.189–1.221)	0.124	28	25	0.381 (0.160–0.909)	0.030	26	27	0.464 (0.200–1.076)	0.073
Male	26	33	0.302 (0.140–0.652)	0.002	28	31	0.880 (0.372–2.086)	0.772	30	29	0.477 (0.211–1.078)	0.075
Histologic grade
G1 + G2	39	41	0.374 (0.178–0.787)	0.010	41	39	0.442 (0.222–0.880)	0.020	39	41	0.635 (0.322–1.254)	0.191
G3 + G4	17	15	0.495 (0.177–1.383)	0.180	15	17	0.644 (0.238–1.743)	0.386	17	15	0.303 (0.105–0.870)	0.026
Radical resection^b
R0	36	30	0.532 0.249–1.136)	0.103	29	37	0.589 0.293–1.184)	0.137	31	35	0.712 0.346–1.466)	0.357
R1 + Rx	20	24	0.378 0.162–0.880)	0.024	26	18	0.368 0.135–1.003)	0.051	25	19	0.305 0.120–0.770)	0.012
Radiation therapy^c
No	42	28	0.462 (0.241–0.885)	0.020	37	33	0.504 (0.271–0.938)	0.031	37	33	0.479 (0.254–0.904)	0.023
Yes	11	19	0.258 (0.068–0.977)	0.046	11	19	0.612 (0.166–2.260)	0.461	12	18	0.725 (0.210–2.498)	0.610
Targeted molecular therapy^d
No	15	14	0.453 (0.187–1.095)	0.079	19	10	0.346 (0.125–0.956)	0.041	16	13	0.397 (0.158–0.995)	0.049
Yes	38	35	0.477 (0.222–1.027)	0.059	30	43	0.668 (0.328–1.359)	0.265	33	40	0.571 (0.282–1.154)	0.118

Abbreviations: HR hazard ratio, CI confidence interval
^a Adjusted for histologic grade, targeted molecular therapy, radiation therapy and radical resection. ^b Information of radical resection was unavailable in 2 patients. ^c Information of radiation therapy was unavailable in 12 patients. ^d Information of targeted molecular therapy was unavailable in 10 patients

ISSN: 1471-230X