Fig. 1

Photographs of liver biopsy demonstrates (a) The portal tract expanded by severe inflammatory cell infiltration, consisting of lymphocytes and plasma cells (H&E × 100); (b) A moderate number of eosinophils and histiocytes, with interface hepatitis and bridging necrosis, are present; no florid duct lesion or broad collapse is clearly seen (H&E × 400); (c) Immunostaining for IgG4 demonstrates that most plasma cells are marked with IgG4, with more than 40 positive plasma cells/high power field; (d) Immunohistochemical staining with CK7 revealed a moderate number of central and peripheral bile ducts without evidence of destruction (lumen × 200)