Table 1 Baseline characteristics of included studies in the meta-analysis
Study | Treatment | Country | Number of patients | Gender (M/F) | Age, year | HBsAg (+) | Tumor size (cm) | Tumor number | Child-Pugh class (A/B) | AFP(ng/mL) | OS (1/3/5 years) % | PFS(1/3/5 years) % | Major complication |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chan (2012) [5] | RHR RFA | China | 29 45 | – | 52 (38–79)d 59 (36–80)d | 26 40 | 2.1 (0.8–5.5)d 2.2 (0.8–6.0)d | – | 29/0 40/5 | 64 (2–167,138)d 90 (1–197,122)d | 89.7/56.5/35.2 83.7/43.1/29.1 | 41.4/24.2/24.2 32.2/12.4/9.3 | 3 (10.3%) 1 (2.2%) |
Eisele (2013) [26] | RHR RFA | Germany | 27 27 | 15/12 20/7 | 60 ± 17e 68 ± 7e | – | 4.0 ± 2.3e 2.8 ± 1.1e | 16/11a 15/12 a | – | – | 100/68/39 96/62/32 | 82/45/28 51/30/11 | 4 (14.8%) 1 (3.7%) |
Liang (2008) [15] | RHR RFA | China | 44 66 | 41/3 60/6 | 48.8 ± 12.0e 54.6 ± 10.8e | 41 60 | ≦3/>3:26/18 ≦3/>3:44/22 | 34/10a 48/18a | 44/0 64/2 | ≦400/>400: 30/14 ≦400/>400: 52/14 | 78.6/44.5/27.6 76.6/48.6/39.9 | – | 30 (68.2%) 2 (3.0%) |
Lu (2020) [18] | RHR RFA | China | 138 194 | 31/8 58/20 | 50.1 ± 10.9e 52.9 ± 11.8e | 126 172 | 2.4 ± 1.1e 2.2 ± 1.0e | 112/26a 162/32a | 138/0 194/0 | ≦20/>20:95/43 ≦20/>20:123/71 | 90.5/81.5/71.8c 91.0/61.0/41.7c | – | 10 (7.2%) 5 (2.6%) |
Song (2015) [16] | RHR RFA | Korea | 39 178 | 31/8 58/20 | 52.5 ± 9.8e 55.4 ± 10.6e | 36 149 | >2: 17 >2: 50 | 7b 22 b | 39/0 172/6 | ≦200/>200: 33/6 ≦200/>200: 164/14 | 88.8/88.8/83.9c 98.7/85.7/72.1c | 71.8/45.1/39.4c 66.1/48.5/43.1c | 4 (10.3%) 4 (2.2%) |
Sun (2017) [20] | RHR RFA | China | 43 57 | 34/9 38/19 | 63 (37–84)d 65 (31–84)d | 21 32 | 1.9 (0.8–3.0)d 1.8 (1.0–3.0)d | 1.2 (1–3) 1.1 (1–2) | 35/1 50/0 | 23 (3–290)d 67 (2–817)d | 97.6/82.7/56.4 98.2/77.2/52.6 | 57.0/32.1/28.6 60.8/26.6/16.6 | 1 (2.3%) 0 |
Umeda (2011) [28] | RHR RFA | Japan | 29 58 | – | ≧65: 16 ≧65: 37 | 8 11 | 3.2 ± 0.57e 2.1 ± 0.3e | ≧3: 4 ≧3: 10 | 29/0 51/7 | ≧100: 4 ≧100: 3 | 93.1/66.8/56.1 94.7/75.1/48.3 | – | – |
Wang (2015) [17] | RHR RFA | China | 128 162 | 113/15 148/14 | 50.2 ± 10.1e 52.7 ± 10.9e | 119 142 | 2.4 ± 0.9e 2.3 ± 0.7e | 89/39a 107/55a | – | ≦20/>20:72/56 ≦20/>20:85/77 | 97.70/84.1/64.5 96.9/73.4/37.0 | – | – |
Xia (2020) [22] | RHR RFA | China | 120 120 | – | – | – | – | – | – | – | 92.5/65.8/43.6 87.5/52.5/38.5 | 85.0/52.4/36.2 74.2/41.7/30.2 | 7 (5.8%) 2 (1.7%) |
Yin (2019) [21] | RHR RFA | China | 57 51 | 41/16 31/20 | 57.1 ± 12.0e 60.3 ± 9.5e | 53 48 | 3.2 ± 2.5e 2.6 ± 0.9e | 52/5a 48/3a | 55/2 46/5 | 167.97 ± 357.23e 266.32 ± 420.28e | 78.9/50.5/29.7 80.3/50.9/26.0 | 68.40/39.4/26.6 62.8/32.8/20.4 | – |