Table 6 The 24-h urine volume, fluid intake and water balance of the tolvaptan and placebo groups from baseline to day 7

24-h urine volume (mL)

Placebo

1666.9 ± 713.5

2019.5 ± 921.4

1920.9 ± 802.5

2099.0 ± 868.2

1968.7 ± 796.5

2066.0 ± 810.0

1993.5 ± 789.3

1826.6 ± 720.4

–

Tolvaptan 7.5 mg

1951.8 ± 848.2

3232.5 ± 1565.2

2999.5 ± 1524.0

2890.1 ± 1386.1

2785.6 ± 1430.2

2841.2 ± 1322.5

2748.2 ± 1256.8

2606.5 ± 1245.3

< 0.001

Tolvaptan 15 mg

1831.4 ± 911.8

3661.0 ± 1791.4

3399.5 ± 1637.1

3139.4 ± 1527.9

2981.8 ± 1402.5

3000.4 ± 1390.7

3019.4 ± 1372.5

2834.9 ± 1312.7

< 0.001

24-h fluid intake (mL)

Placebo

1854.9 ± 708.7

1973.1 ± 782.2

1929.6 ± 767.1

1995.3 ± 839.5

1860.9 ± 806.8

1953.7 ± 791.7

1874.3 ± 802.2

1665.4 ± 727.3

–

Tolvaptan 7.5 mg

2042.0 ± 1059.5

2505.3 ± 1152.8

2643.7 ± 1255.9

2447.3 ± 1167.9

2381.9 ± 1128.3

2339.4 ± 1087.3

2416.5 ± 1337.0

2175.3 ± 1111.1

< 0.001

Tolvaptan 15 mg

1953.4 ± 964.6

2745.9 ± 1318.1

2795.4 ± 1369.0

2605.1 ± 1291.5

2537.6 ± 1306.4

2456.6 ± 1237.5

2493.4 ± 1320.4

2295.2 ± 1141.4

< 0.001

Water balance

Placebo

189.8 ± 714.1

− 47.9 ± 746.7

11.9 ± 609.0

− 105.1 ± 793.7

− 105.0 ± 756.1

− 115.0 ± 694.1

− 116.7 ± 768.9

− 155.0 ± 665.1

–

Tolvaptan 7.5 mg

83.1 ± 1158.7

− 727.1 ± 1352.0

− 364.9 ± 1255.9

− 451.3 ± 1227.9

− 409.5 ± 1174.4

− 498.6 ± 1180.2

− 334.5 ± 1264.2

− 428.8 ± 941.1

< 0.001

Tolvaptan 15 mg

123.5 ± 873.3

− 921.3 ± 1352.3

− 610.8 ± 1137.8

− 539.0 ± 1069.1

− 447.0 ± 1046.9

− 546.7 ± 1036.3

− 529.7 ± 1039.7

− 553.1 ± 1007.0

< 0.001