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Table 3 Tumor type, HER2 protein expression and HER2 gene copy number in liquid biopsy in patients with or without HER2 gene amplification in tumor cells visualized by FISH examination

From: HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery

  R < 2.2
N = 41 (62%)
R ≥ 2.2
N = 26 (38%)
X2
p
Tumor type (n = 67)
 GC patients 23 (62) 14 (38) 0.033
0.85
 EGJC patients 18 (60) 12 (40)
IHC (n = 18)
 Negative 5 (56) 4 (44) 2.925
0.23
 Low expression of HER2 (+ or ++) 3 (50) 3 (50)
 High expression of HER2 (+++) 0 (0) 3 (100)
HER2 gene copy number in serum (n = 61)
 Below the median 17 (53) 15 (47) 2.420
0.12
 Above the median 21 (72) 8 (28)
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