Table 3 Tumor type, HER2 protein expression and HER2 gene copy number in liquid biopsy in patients with or without HER2 gene amplification in tumor cells visualized by FISH examination
R < 2.2 N = 41 (62%) | R ≥ 2.2 N = 26 (38%) | X2 p | |
|---|---|---|---|
Tumor type (n = 67) | |||
GC patients | 23 (62) | 14 (38) | 0.033 0.85 |
EGJC patients | 18 (60) | 12 (40) | |
IHC (n = 18) | |||
Negative | 5 (56) | 4 (44) | 2.925 0.23 |
Low expression of HER2 (+ or ++) | 3 (50) | 3 (50) | |
High expression of HER2 (+++) | 0 (0) | 3 (100) | |
HER2 gene copy number in serum (n = 61) | |||
Below the median | 17 (53) | 15 (47) | 2.420 0.12 |
Above the median | 21 (72) | 8 (28) | |