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Table 2 Differences in demographic and clinical factors between groups of patients with high and low number of HER2 gene copies in liquid biopsy

From: HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery

Feature HER2 gene copy number in serum X2
p
Below the median N = 38 (49%) Above the median N = 40 (51%)
Age (n = 78)
 < 62 17 (50) 17 (50) 0.04
0.8
 ≥ 62 21 (48) 23 (52)
Gender (n = 78)
 Male 29 (45) 35 (55) 1.655
2.2
 Female 9 (64) 5 (36)
Histopathological diagnosis (n = 68)
 Tubular 15 (54) 13 (46) 0.983
0.9
 Mucinous 5 (64) 3 (36)
 Poorly cohesive 10 (53) 9 (47)
 Poorly differentiated 4 (67) 2 (33)
 No data 3 (43) 4 (57)
Laurent type (n = 67)
 Intestinal 10 (56) 8 (44) 3.110
0.37
 Diffuse 9 (69) 4 (31)
 Mixed 2 (29) 5 (71)
 No data 15 (52) 14 (48)
Grading (n = 67)
 G1 1 (33) 2 (67) 2.271
0.69
 G2 16 (57) 12 (43)
 G3 15 (58) 11 (42)
 G4 0 (0) 1 (100)
 ND 4 (44) 5 (56)
cTNM (n = 67)
 1A-IIIA 15 (65) 8 (35) 1.859
0.17
 IIIB-IV 21 (48) 23 (52)
IHC (n = 19)
 Negative 4 (44) 3 (56) 0.686
0.7
 Low expression of HER2 (+ or ++) 4 (80) 1 (20)
 High expression of HER2 (+++) 2 (67) 1 (33)
Treatment (n = 78)
 PAL 10 (40) 15 (60) 5.757
0.33
 CHTH 0 (0) 3 (100)
 CHRTH 1 (25) 3 (75)
 CHTH + OP 14 (56) 11 (44)
 CHRTH + OP 5 (56) 4 (44)
 OP 5 (42) 7 (58)
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