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Table 2 Differences in demographic and clinical factors between groups of patients with high and low number of HER2 gene copies in liquid biopsy

From: HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery

Feature

HER2 gene copy number in serum

X2

p

Below the median N = 38 (49%)

Above the median N = 40 (51%)

Age (n = 78)

 < 62

17 (50)

17 (50)

0.04

0.8

 ≥ 62

21 (48)

23 (52)

Gender (n = 78)

 Male

29 (45)

35 (55)

1.655

2.2

 Female

9 (64)

5 (36)

Histopathological diagnosis (n = 68)

 Tubular

15 (54)

13 (46)

0.983

0.9

 Mucinous

5 (64)

3 (36)

 Poorly cohesive

10 (53)

9 (47)

 Poorly differentiated

4 (67)

2 (33)

 No data

3 (43)

4 (57)

Laurent type (n = 67)

 Intestinal

10 (56)

8 (44)

3.110

0.37

 Diffuse

9 (69)

4 (31)

 Mixed

2 (29)

5 (71)

 No data

15 (52)

14 (48)

Grading (n = 67)

 G1

1 (33)

2 (67)

2.271

0.69

 G2

16 (57)

12 (43)

 G3

15 (58)

11 (42)

 G4

0 (0)

1 (100)

 ND

4 (44)

5 (56)

cTNM (n = 67)

 1A-IIIA

15 (65)

8 (35)

1.859

0.17

 IIIB-IV

21 (48)

23 (52)

IHC (n = 19)

 Negative

4 (44)

3 (56)

0.686

0.7

 Low expression of HER2 (+ or ++)

4 (80)

1 (20)

 High expression of HER2 (+++)

2 (67)

1 (33)

Treatment (n = 78)

 PAL

10 (40)

15 (60)

5.757

0.33

 CHTH

0 (0)

3 (100)

 CHRTH

1 (25)

3 (75)

 CHTH + OP

14 (56)

11 (44)

 CHRTH + OP

5 (56)

4 (44)

 OP

5 (42)

7 (58)