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Table 1 Demographic and clinical data of cancer patients included in the study

From: HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery

Feature N (%) Gastric cancer N = 49 (56%) Esophagogastric junction cancer N = 38 (44%) X2
p
Age (n = 87)
 < 62 39 (45) 24 (62) 15 (38) 0.782
 ≥ 62 48 (55) 25 (52) 23 (48) 0.38
Gender (n = 87)
 Male 72 (83) 41 (57) 31 (43) 0.066
 Female 15 (17) 8 (53) 7 (47) 0.8
Histopathological diagnosis (n = 76)
 Tubular 33 (43) 21 (64) 12 (36) 12.263
 Mucinous 9 (12) 2 (22) 7 (78)
 Poorly cohesive 20 (26) 13 (65) 7 (35)
 Poorly differentiated 7 (9) 7 (100) 0 (0)
 No data 7 (9) 6 (86) 1 (14) 0.015
Laurent type (n = 75)
 Intestinal 21 (28) 17 (81) 4 (19) 11.802
 Diffuse 15 (20) 13 (87) 2 (13)
 Mixed 7 (9) 4 (57) 3 (43)
 No data 32 (43) 14 (44) 18 (56) 0.008
Grading (n = 75)
 G1 3 (4) 1 (33) 2 (67) 9.391
 G2 33 (44) 16 (48) 17 (52)
 G3 28 (37) 23 (82) 5 (18)
 G4 1 (1) 1 (100) 0 (0)
 No data 10 (13) 7 (70) 3 (30) 0.052
cTNM (n = 75)
 IA-IIIA 27 (36) 21 (78) 6 (22) 3.476
 IIIB-IV 48 (63) 27 (56) 21 (44) 0.062
IHC results (n = 19)
 Negative 9 (47) 5 (56) 4 (44) 0.445
 Low expression of HER2 (+ or ++) 7 (37) 5 (71) 2 (29)
 High expression of HER2 (+++) 3 (16) 2 (67) 1 (33) 0.8
Treatment (n = 87)
 PAL 26 (30) 17 (65) 9 (35) 63.079
 CHTH 3 (3) 3 (100) 0 (0)
 CHRTH 5 (6) 0 (0) 5 (100)
 CHTH + OP 29 (33) 29 (100) 0 (0)
 CHRTH + OP 9 (10) 0 (0) 9 (100)
 OP 15 (17) 0 (0) 15 (100) < 0.00000
  1. PAL palliative treatment when primary tumor was inoperable, CHTH chemotherapy for gastric cancer, when the tumor was initially assessed as resectable and after neoadjuvant CHTH it was unresectable, CHRTH chemoradiotherapy for gastroesophageal junction cancer, when the tumor was initially assessed as resectable and after neoadjuvant CHRTH it was unresectable, CHTH + OP for gastric cancer when the combination of preoperative chemotherapy and gastrectomy has been completed, CHRTH + OP for gastroesophageal junction cancer when combination of preoperative chemoradiotherapy and esophageal resection has been completed
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