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Table 1 Demographic and clinical data of cancer patients included in the study

From: HER2 gene assessment in liquid biopsy of gastric and esophagogastric junction cancer patients qualified for surgery

Feature

N (%)

Gastric cancer N = 49 (56%)

Esophagogastric junction cancer N = 38 (44%)

X2

p

Age (n = 87)

 < 62

39 (45)

24 (62)

15 (38)

0.782

 ≥ 62

48 (55)

25 (52)

23 (48)

0.38

Gender (n = 87)

 Male

72 (83)

41 (57)

31 (43)

0.066

 Female

15 (17)

8 (53)

7 (47)

0.8

Histopathological diagnosis (n = 76)

 Tubular

33 (43)

21 (64)

12 (36)

12.263

 Mucinous

9 (12)

2 (22)

7 (78)

 Poorly cohesive

20 (26)

13 (65)

7 (35)

 Poorly differentiated

7 (9)

7 (100)

0 (0)

 No data

7 (9)

6 (86)

1 (14)

0.015

Laurent type (n = 75)

 Intestinal

21 (28)

17 (81)

4 (19)

11.802

 Diffuse

15 (20)

13 (87)

2 (13)

 Mixed

7 (9)

4 (57)

3 (43)

 No data

32 (43)

14 (44)

18 (56)

0.008

Grading (n = 75)

 G1

3 (4)

1 (33)

2 (67)

9.391

 G2

33 (44)

16 (48)

17 (52)

 G3

28 (37)

23 (82)

5 (18)

 G4

1 (1)

1 (100)

0 (0)

 No data

10 (13)

7 (70)

3 (30)

0.052

cTNM (n = 75)

 IA-IIIA

27 (36)

21 (78)

6 (22)

3.476

 IIIB-IV

48 (63)

27 (56)

21 (44)

0.062

IHC results (n = 19)

 Negative

9 (47)

5 (56)

4 (44)

0.445

 Low expression of HER2 (+ or ++)

7 (37)

5 (71)

2 (29)

 High expression of HER2 (+++)

3 (16)

2 (67)

1 (33)

0.8

Treatment (n = 87)

 PAL

26 (30)

17 (65)

9 (35)

63.079

 CHTH

3 (3)

3 (100)

0 (0)

 CHRTH

5 (6)

0 (0)

5 (100)

 CHTH + OP

29 (33)

29 (100)

0 (0)

 CHRTH + OP

9 (10)

0 (0)

9 (100)

 OP

15 (17)

0 (0)

15 (100)

< 0.00000

  1. PAL palliative treatment when primary tumor was inoperable, CHTH chemotherapy for gastric cancer, when the tumor was initially assessed as resectable and after neoadjuvant CHTH it was unresectable, CHRTH chemoradiotherapy for gastroesophageal junction cancer, when the tumor was initially assessed as resectable and after neoadjuvant CHRTH it was unresectable, CHTH + OP for gastric cancer when the combination of preoperative chemotherapy and gastrectomy has been completed, CHRTH + OP for gastroesophageal junction cancer when combination of preoperative chemoradiotherapy and esophageal resection has been completed