Parameters | Derivation cohort (n = 629) | Validation cohort (n = 314) | P value |
---|---|---|---|
Age, years | 55 (14) | 53 (14) | 0.37 |
Male sex | 484 (76.9%) | 243 (77.3%) | 0.88 |
BMI | 24.16 (3.92) | 23.88 (3.78) | 0.30 |
Systolic blood pressure (mmHg) | 115 (22) | 112 (25) | 0.31 |
Cirrhosis etiology | |||
Hepatitis B virus n (%) | 629 (100%) | 314 (100%) | 1.00 |
Variceal bleeding, n (%) | 369 (58.7%) | 167 (53.2%) | 0.11 |
Heart rate | 78 (21) | 80 (22) | 0.81 |
Hemoglobin, g/L | 97 (46) | 99 (49.25) | 0.72 |
Total leukocyte count, × 109/L | 3.71 (1.8) | 3.9 (2.85) | 0.61 |
Platelets, × 109/L | 66 (52) | 73 (56) | 0.27 |
Alanine aminotransferase, IU/L | 27 (26) | 27 (27.25) | 0.83 |
Creatinine, μmol/L | 78 (26.25) | 76 (23) | 0.06 |
Sodium, mmol/L | 139.8 (5.5) | 139.6 (4.93) | 0.64 |
Bilirubin, mmol/L | 24 (28.72) | 23.6 (26.6) | 0.71 |
Albumin, g/L | 31.1 (8.45) | 31.5 (9.53) | 0.97 |
Triglyceride | 0.73 (0.46) | 0.79 (0.51) | 0.09 |
Cholesterol, mmol/L | 3.01 (1.31) | 3.1 (1.33) | 0.32 |
High density lipoprotein, mmol/L | 0.83 (0.49) | 0.84 (0.49) | 0.58 |
Low-density lipoprotein, mmol/L | 1.63 (0.97) | 1.64 (1.05) | 0.59 |
International normalized ratio | 1.22 (0.3) | 1.23 (0.33) | 0.77 |
Fibrinogen, g/L | 1.76 (0.85) | 1.78 (0.88) | 0.45 |
Hepatocellular carcinoma | 137 (21.7%) | 76 (24.2%) | 0.40 |
Previous bleeding, n (%) | 203 (32.2%) | 119 (35.9%) | 0.09 |
Ascites, n (%) | 367 (58.3%) | 183 (58.2%) | 0.98 |
Hepatic Encephalopathy, n (%) | 56 (8.9%) | 22 (7.0%) | 0.32 |
β-blocker use, n (%) | 133 (21.1%) | 73 (23.2%) | 0.46 |
QTc, ms | 435 (33) | 433.5 (37) | 0.57 |
QTc prolongation, n (%) | 148 (23.5%) | 81 (25.7%) | 0.44 |
PRBC transfusion (%) | 170 (27%) | 105 (27.8%) | 0.04 |
> 2 PRBC transfusion (%) | 57 (33.5%) | 43 (41.0%) | 0.03 |
Endoscopic treatment, n (%) | 260 (41.3%) | 153 (40.5%) | 0.03 |
TIPS treatment, n (%) | 23 (3.6%) | 11 (2.9%) | 0.91 |
6-Week death, n (%) | 66 (10.4%) | 34 (10.8%) | 0.75 |
Prognostic scores | |||
Child–Pugh score | 8 (4) | 8 (4) | 0.86 |
Child–Pugh A | 202 (32.1%) | 93 (29.6%) | |
Child–Pugh B | 264 (42%) | 141 (44.9%) | |
Child–Pugh C | 163 (25.9%) | 80 (25.5%) | |
MELD | 10.98 (7.76) | 10.8 (7.02) | 0.19 |
ALBI | −1.72 (0.96) | −1.71 (0.99) | 0.89 |
D’Amico model | −1.32 (1.39) | −1.27 (1.4) | 0.75 |
Augustin model | −2.95 (2.29) | −2.95 (2.22) | 0.97 |
Glasgow-Blatchford score | 9 (7) | 9 (8) | 0.74 |
AIMS65 | 1 (1) | 1 (1) | 0.88 |