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Table 1 Patient characteristics

From: Small intestinal mucosal injury and its risk factors in patients with gastrointestinal cancer who developed complicated fluoropyrimidine-induced diarrhea

 

Total

Gastric cancer (n = 256)

Colorectal cancer (n = 280)

Sex

   

 Male/female

357/179

189/67

168/112

Age

   

 Median (range)

66 (11–87)

66 (22–87)

66 (11–86)

ECOG PS

   

 0–1/≥ 2

450/86

204/52

246/34

Stage

   

 Advanced

433 (81%)

225 (88%)

208 (74%)

 Postoperative recurrence

103 (19%)

31 (12%)

72 (26%)

Metastatic sites

   

 Lymph node

279 (52%)

184 (72%)

95 (34%)

 Liver

253 (47%)

97 (38%)

156 (56%)

 Peritoneum

131 (24%)

101 (39%)

60 (21%)

Number of metastatic sites

   

 0–1/≥ 2

233/303

113/143

120/160

Fluoropyrimidine type

   

 5-FU

262 (49%)

43 (17%)

219 (72%)

 S-1

182 (34%)

178 (70%)

4 (1%)

 Capecitabine

85 (16%)

32 (12%)

53 (19%)

 Others

7 (1%)

3 (1%)

4 (1%)

Molecular-targeted drugs

   

 Trastuzumab

35

35

0

 Cetuximab/panitumumab

25

0

25

 Bevacizumab

116

0

116

Chemotherapy regimens

   

 Fluoropyrimidine alone

69 (13%)

55 (21%)

14 (5%)

 Combination chemotherapy

467 (87%)

201 (79%)

266 (95%)

  Platinum

389

161

228

  Irinotecan

29

0

29

  Taxane

24

24

0

  Others

17

16

1

  1. ECOG PS Eastern Cooperative Oncology Group performance status, 5-FU 5-fluorouracil