Table 1 Comparison of clinicopathologic features of EGC among different locations
Clinicopathologic factor | Tumor location | p value | ||||
|---|---|---|---|---|---|---|
Cardia | Fundus–corpus | Antrum–angularis–pylorus | Non-cardia | Total | ||
Number | 70 (21.9) | 78 (24.5) | 181 (56.7) | 259 (78.1) | 329 | NS |
Gender | ||||||
Male | 50 (71.4) | 53 (67.9) | 121 (66.9) | 174 (67.2) | 224 (68.1) | NS |
Female | 20 (28.6) | 25 (32.1) | 60 (33.1) | 85 (32.8) | 105 (31.9) | |
M/F ratio | 2.50 | 2.12 | 2.02 | 2.05 | 2.13 | |
Age (year) | ||||||
≤ 40 | 0 (0.0) | 2 (2.6) | 12 (6.6) | 14 (5.4) | 14 (4.3) | NS |
41–69 | 54 (77.1) | 62 (79.5) | 139 (76.8) | 201 (77.6) | 255 (77.5) | |
≥ 70 | 16 (22.9) | 14 (18.0) | 30 (16.6) | 44 (17.0) | 60 (18.2) | |
Average (SD) | 64.33 ± 7.14 | 60.77 ± 10.18 | 58.26 ± 11.94 | 59.01 ± 11.48 | 60.15 ± 10.91 | < 0.01 |
Macroscopic feature | ||||||
I | 5 (7.1) | 1 (1.3) | 8 (4.4) | 9 (3.5) | 14 (4.3) | < 0.05 |
IIa | 2 (2.9) | 2 (2.6) | 8 (4.4) | 10 (3.9) | 12 (3.6) | |
IIb | 16 (22.9) | 14 (17.9) | 18 (9.9) | 32 (12.4) | 48 (14.6) | |
IIc | 23 (32.9) | 24 (30.8) | 58 (32.0) | 82 (31.7) | 105 (31.9) | |
III | 24 (34.3) | 37 (47.4) | 89 (49.2) | 126 (48.6) | 150 (45.6) | |
I + IIa | 7 (10.0) | 3 (3.8) | 16 (8.8) | 19 (7.3) | 26 (7.9) | < 0.05 |
IIb | 16 (22.9) | 14 (17.9) | 18 (9.9) | 32 (12.4) | 48 (14.6) | |
IIc + III | 47 (67.1) | 61 (78.2) | 147 (81.2) | 208 (80.3) | 255 (77.5) | |
Size (cm) | ||||||
≤ 0.9 | 11 (15.7) | 15 (19.2) | 34 (18.8) | 49 (18.9) | 60 (18.2) | NS |
1–1.9 | 27 (38.6) | 27 (34.6) | 59 (32.6) | 86 (33.2) | 113 (34.3) | |
2–2.9 | 20 (28.6) | 21 (26.9) | 51 (28.2) | 72 (27.8) | 92 (28.0) | |
> 3 | 12 (17.1) | 15 (19.2) | 37 (20.4) | 52 (20.1) | 64 (19.5) | |
Invasion depth | ||||||
M2 | 9 (12.9) | 17 (21.8) | 42 (23.2) | 59 (22.8) | 68 (20.7) | NS |
M3 | 19 (27.1) | 19 (24.4) | 52 (28.8) | 71 (27.4) | 90 (27.4) | |
SM1 | 10 (14.3) | 10 (12.8) | 23 (12.7) | 33 (12.7) | 43 (13.1) | |
SM2 | 32 (45.7) | 32 (41.0) | 64 (35.4) | 96 (37.1) | 128 (38.9) | |
Histology type | ||||||
Tubular adenocarcinoma | 40 (57.1) | 42 (53.8) | 81 (44.8) | 123 (47.5) | 163 (49.5) | < 0.01 |
Papillary adenocarcinoma | 13 (18.6) | 2 (2.6) | 11 (6.1) | 13 (5.0) | 26 (7.9) | |
Micropapillary adenocarcinoma | 1 (1.4) | 1 (1.3) | 2 (1.1) | 3 (1.2) | 4 (1.2) | |
Poorly cohesive carcinoma | 2 (2.9) | 14 (17.9) | 32 (17.7) | 46 (17.8) | 48 (14.6) | |
Mucinous carcinoma | 1 (1.4) | 2 (2.6) | 1 (0.6) | 3 (1.2) | 4 (1.2) | |
Mixed PCC and adenocarcinoma | 6 (8.6) | 15 (19.2) | 45 (24.9) | 60 (23.2) | 66 (20.1) | |
Mixed mucinous and tubular adenocarcinoma | 3 (4.3) | 1 (1.3) | 5 (2.8) | 6 (2.3) | 9 (2.7) | |
Others (neuroendocrine/medullary/adenosqumous carcinoma) | 4 (5.7) | 1 (1.3) | 4 (2.2) | 5 (1.9) | 9 (2.7) | |
Differentiation | ||||||
Well | 17 (24.3) | 9 (11.5) | 17 (9.4) | 26 (10.0) | 43 (13.1) | < 0.05 |
Moderate | 42 (60.0) | 37 (47.4) | 83 (45.9) | 120 (46.3) | 162 (49.2) | |
Poorly | 11 (15.7) | 32 (41.0) | 81 (44.8) | 113 (43.6) | 124 (37.7) | |
Lymphovascular invasion | ||||||
Absence | 59 (84.3) | 69 (88.5) | 149 (82.3) | 218 (84.2) | 277 (84.2) | NS |
Presence | 11 (15.7) | 9 (11.5) | 32 (17.7) | 41 (15.8) | 52 (15.8) | |
Perineural invasion | ||||||
Absence | 67 (95.7) | 76 (97.4) | 172 (95.0) | 248 (95.8) | 315 (95.7) | NS |
Presence | 3 (4.3) | 2 (2.6) | 9 (5.0) | 11 (4.2) | 14 (4.3) | |
HP | ||||||
Absence | 52 (74.3) | 49 (62.8) | 131 (72.4) | 180 (69.5) | 232 (70.5) | NS |
Presence | 18 (25.7) | 29 (37.2) | 50 (27.6) | 79 (30.5) | 97 (29.5) | |
LNM | ||||||
Absence | 63 (90.0) | 66 (84.6) | 151 (83.4) | 217 (83.8) | 280 (85.1) | NS |
Presence | 7 (10.0) | 12 (15.4) | 30 (16.6) | 42 (16.2) | 49 (14.9) | |
N1 | 5 (7.1) | 6 (7.7) | 13 (7.2) | 19 (7.3) | 24 (7.3) | |
N2 | 1 (1.4) | 5 (6.4) | 11 (6.1) | 16 (6.2) | 17 (5.2) | |
N3 | 1 (1.4) | 1 (1.3) | 6 (3.3) | 7 (2.7) | 8 (2.4) | |