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Table 3 Meta-regression of VCE retention rate

From: Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta-analysis

  Univariate meta-regression Multivariate meta-regressiona
Coefficient (95% CI) Studies, n P value Coefficient (95% CI) Studies, n P value
Study period midpointb − 0.34 (− 0.53 to − 0.14) 245 .0006 − 0.24 (− 0.46 to − 0.02) 245 .0348
Study design
 RCT Reference 25 Reference
 Prospective − 0.49 (− 3.36 to 2.38) 115 .7382
 Retrospective 1.05 (− 1.71 to 3.81) 149 .4559
Study region
 Asia Reference 106 Reference
 Europe − 1.31 (− 2.93 to 0.31) 120 .1125
 North America − 0.64 (− 2.71 to 1.43) 50 .5464
 Oceania 0.52 (− 4.56 to 5.61) 7 .8402
 Multiple − 2.31 (− 6.85 to 2.24) 6 .3195
Patient groups
 Population-based Reference 160 Reference Reference 160 Reference
 Known IBDb 3.07 (0.53 to 5.61) 30 .0176 4.29 (1.46 to 7.12) 30 .0029
 OGIB 1.43 (− 0.30 to 3.17) 67 .1058
 Abdominal pain or diarrhea 4.19 (− 0.73 to 9.11) 6 .0948 3.14 (− 1.75 to 8.04) 6 .2084
 Suspected IBD 1.49 (− 3.31 to 6.28) 9 .5432
 NSAIDs users − 4.62 (− 10.16 to 0.92) 5 .1020
 Mixed high-risk group − 0.90 (− 5.40 to 3.61) 7 .6966
 Suspected tumor − 3.12 (− 8.83 to 2.59) 5 .2847   
Male − 3.37 (− 9.99 to 3.25) 261 .3186
Mean age − 0.02 (− 0.09 to 0.04) 219 .5238
VCE type
 SBCE Reference 217 Reference Reference 217 Reference
 After PCEb − 4.43 (− 7.67 to − 1.18) 15 .0074 − 5.04 (− 8.75 to − 1.33) 15 .0077
 CCE − 2.98 (− 5.68 to − 0.29) 26 .0297 − 2.60 (− 6.06 to 0.86) 26 .1401
 ECE − 3.66 (− 7.02 to − 0.31) 18 .0323 − 3.90 (− 9.05 to 1.26) 18 .1390
 GCE − 2.82 (− 6.31 to 0.68) 13 .1139
  1. Multivariate meta-regression was performed when the univariate meta-regression P value was ≤ .1
  2. Moderators had a significant effect on VCE retention rate