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Table 2 Pooled rate of each VCE adverse events and subgroup analysis based on VCE types

From: Adverse events of video capsule endoscopy over the past two decades: a systematic review and proportion meta-analysis

VCE type and the rate of adverse events VCE types
ECE GCE SBCE CCE
AER, % (95% CI) Study, n Events/VCE, n AER, % (95% CI) Study, n Events/VCE, n AER, % (95% CI) Study, n Events/VCE, n AER, % (95% CI) Study, n Events/VCE, n
Retention 0.11 (0.00–0.46) 18 8/1622 0.39 (0.19–0.64) 13 40/5072 0.93 (0.75–1.12) 217 1017/74115 0.26 (0.00–0.77) 26 22/3432
Esophagus IE 9.05 (2.43–18.88) 10 103/825 9.06 (3.95–15.76) 2 9/99   
Stomach IE 14.47 (3.65–30.35) 4 52/326 5.27 (0.36–14.24) 6 40/3494 4.18 (0.00–13.89) 2 11/207  
Small bowel IE   13.91 (3.40–29.51) 5 174/863 13.17 (11.88–14.50) 245 9507/62956 3.99 (2.51–5.75) 21 136/3004
Colon IE     19.19 (14.06–24.88) 37 874/4483
Swallow disorder 1.76 (0.88–2.86) 19 39/1741 0.00 (0.00–0.02) 11 2/4451 0.85 (0.41–1.42) 95 336/26021 0.04 (0.00–0.18) 27 12/4427
Aspiration 0.00 (0.00–0.82) 3 0/220 0.00 (0.00–0.27) 7 0/641 0.00 (0.00–0.00) 57 5/19866 0.00 (0.00–0.00) 18 0/2671
Technical failure 1.16 (0.52–1.98) 14 24/1596 0.20 (0.00–0.98) 8 6/843 0.83 (0.51–1.21) 98 300/31068 1.76 (0.76–3.06) 26 66/3790
Procedural adverse events 6.48 (2.65–11.65) 19 133/1695 0.09 (0.00–0.93) 8 7/4098 0.00 (0.00–0.05) 59 20/9378 0.81 (0.15–1.80) 21 33/3040
VCE type and the rate of adverse events VCE types Overall
After PCE P value between groups AER, % (95% CI) Study, n Events/VCE, n I2, % Egger test P value
AER, % (95% CI) Study, n Events/VCE, n
Retention 0.09 (0.00–0.34) 15 9/2501 <.0001 0.73 (0.59–0.89) 289 1096/86742 70.6 .6063
Esophagus IE   .9523 9.05 (3.14–17.33) 12 112/924 92.8 .7632
Stomach IE   .3350 7.69 (2.45–15.21) 12 103/4027 95.5 .0017
Small bowel IE 3.79 (0.12–11.08) 7 85/1268 .0001 12.08 (10.89–13.32) 278 9902/68091 95.6 .1315
Colon IE   19.19 (14.06–24.88) 37 874/4483 95.2 .1393
Swallow disorder 7.80 (0.00–26.93) 3 37/630 .0001 0.75 (0.43–1.13) 155 426/37270 89.7 .0000
Aspiration 0.00 (0.00; 3.34) 1 0/51 .5201 0.00 (0.00–0.00) 86 5/23449 0.00 .0000
Technical failure   .0707 0.94 (0.65–1.28) 146 396/37297 83.4 .0000
Procedural adverse events 4.72 (1.35–9.73) 1 5/106 .0001 0.67 (0.32–1.10) 108 198/18317 84.1 .0000
  1. AER, adverse event rate; CI, confidence interval; IE, incomplete examination. P value between groups < .05 indicated a significant difference of adverse event rate between various VCE types. Egger test P value < .05 showed an obvious publication bias