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Table 2 Factors associated with the presence of liver metastases at diagnosis of small bowel cancer

From: Frequency, prognosis and treatment modalities of newly diagnosed small bowel cancer with liver metastases

Variables

Univariate logistic model

Multivariate logistic model

OR (95% CI)

P value

OR (95% CI)

P value

Age

 < 40

Reference

 

NA

 

 40–59

0.98 (0.73–1.30)

0.860

  

 60–79

0.95 (0.72–1.26)

0.725

  

 ≥ 80

0.82 (0.60–1.13)

0.229

  

Race

 Black

Reference

 

NA

 

 White

1.05 (0.90–1.22)

0.528

  

 Othersa

0.90 (0.67–1.20)

0.474

  

 Unknown

0.18 (0.06–0.57)

0.004

  

Gender

 Male

Reference

 

NA

 

 Female

0.96 (0.86–1.08)

0.501

  

Insurance status

 No

Reference

 

NA

 

 Yes

0.81 (0.59–1.10)

0.175

  

 Unknown

0.44 (0.25–0.77)

0.004

  

Marital status

 Unmarried

Reference

 

NA

 

 Married

1.03 (0.92–1.16)

0.583

  

 Unknown

0.83 (0.64–1.08)

0.171

  

Primary site

 Duodenum

Reference

 

Reference

 

 Jejunum

0.95 (0.76–1.19)

0.654

1.38 (1.07–1.78)

0.012

 Ileum

1.37 (1.19–1.58)

 < 0.001

2.06 (1.70–2.50)

 < 0.001

 Other siteb

0.81 (0.48–1.37)

0.429

1.18 (0.66–2.09)

0.580

 Unknown

1.69 (1.46–1.96)

 < 0.001

2.28 (1.89–2.74)

 < 0.001

Grade

 I

Reference

 

Reference

 

 II

1.25 (1.07–1.47)

0.005

1.11 (0.92–1.34)

0.263

 III

1.96 (1.62–2.37)

 < 0.001

1.54 (1.21–1.96)

0.001

 IV

1.92 (1.24–2.98)

0.003

2.54 (1.56–4.12)

 < 0.001

 Unknown

1.97 (1.71–2.27)

 < 0.001

1.69 (1.43–2.00)

 < 0.001

Histologic type

 Adenocarcinoma

Reference

 

Reference

 

 NEC

0.73 (0.65–0.83)

 < 0.001

0.98 (0.80–1.18)

0.800

 GISS

0.41 (0.32–0.51)

 < 0.001

0.56 (0.41–0.75)

 < 0.001

T stage

 T1

Reference

 

Reference

 

 T2

1.25 (0.95–1.66)

0.116

0.57 (0.40–0.80)

0.001

 T3

2.33 (0.95–1.66)

 < 0.001

0.71(0.52–0.97)

0.029

 T4

3.29 (1.85–2.94)

 < 0.001

0.94 (0.69–1.28)

0.679

 Unknown

6.27 (4.95–7.95)

 < 0.001

1.62 (1.19–2.21)

0.002

Tumor size, cm

 0–1

Reference

 

Reference

 

 1–2

4.62 (3.40–6.27)

 < 0.001

3.83 (2.66–5.52)

 < 0.001

 2–5

6.76 (5.04–9.07)

 < 0.001

5.53 (3.85–7.94)

 < 0.001

 > 5

4.32 (3.14–5.94)

 < 0.001

4.38 (2.91–6.59)

 < 0.001

 Unknown

12.4 (9.19–16.6)

 < 0.001

6.75 (4.67–9.73)

 < 0.001

N stage

 N0

Reference

 

Reference

 

 N1

2.13 (1.89–2.41)

 < 0.001

1.87 (1.60–2.18)

 < 0.001

 N2

1.53 (1.12–2.09)

0.008

1.19 (0.84–1.69)

0.339

 Unknown

5.89 (4.68–7.40)

 < 0.001

2.12 (1.62–2.77)

 < 0.001

Extrahepatic metastatic sites to bone, lung, and brain, No

 0

Reference

 

Reference

 

 1

8.10 (6.24–10.5)

 < 0.001

5.14 (3.86–6.84)

 < 0.001

 2

7.41 (2.76–19.9)

 < 0.001

4.35 (1.53–12.3)

0.006

 Unknown

10.9 (6.94–17.2)

 < 0.001

6.29 (3.89–10.2)

 < 0.001

  1. CI confidence interval, OR odds ratio, NEC neuroendocrine carcinoma, GISS gastrointestinal stromal sarcoma
  2. aAsian and American Indians
  3. bMeckels diverticulum, and overlapping lesion of small intestine