Fig. 1

Histologic and immunohistochemistry analyses of the renal and hepatic lesions identified in the proband. a and b: Kidney biopsy: round cell neoplasia of the kidney (renal angiomyolipoma). a) HE: haematoxylin and eosin stain, b) Melan A: melanoma antigen. c, d, e and f: Liver biopsy (low grade endocrine neoplasia). c) HE: haematoxylin and eosin stain, d) CGA: chromogranin A antigen, e) HE: haematoxylin and eosin stain, f) Sinapto: synaptophysin (HE and IHC, 200x)