Author [year] | Region | Study design | Enrollment period | Type of disease | Number of patients included | Diagnostic criteria of HBV | Groups | Number of patients in control/ETV plus Tα1 (n) | Intervention method |
---|---|---|---|---|---|---|---|---|---|
Shi TM [2013] [25] | Gansu Province, Jiayuguan | RCT | 2009–2012 | HBC | 30 | Diagnostic Criteria of HBV revised by Xian National Viral Hepatitis Conference in 2000 | CG VS. EG | 15 15 | ETV 0.5 mg, once per day, treated for 48 weeks. ETV 0.5 mg, once per day, combined with Tα1 injection 1.6 mg, twice per week, treated for 24 weeks, and then single ETV 0.5 mg, once per day, treated until 48 weeks. |
Diao YH [2017] [22] | Henan Province, Nanyang | RCT | 2013.4-2014.4 | CHBC | 80 | Guidelines for prevention and treatment of chronic hepatitis B in 2010 | CG VS. EG | 40 40 | ETV 0.5 mg, once per day, treated for 24 weeks. ETV 0.5 mg, once per day, combined with Tα1 injection 1.6 mg, twice per week, treated for 24 weeks. |
Wu XN [2018] [23] | China | RCT | 2013.01-2015.09 | CHBC | 690 | NA | CG VS. EG | 339 351 | After 26 weeks of ETV treatment (0.5 mg per day), patients were randomly assigned to receive ETV (0.5 mg per day) or combination with Tα1 injection (1.6 mg twice per week) for 52 weeks. |
Wang XR [2016] [26] | Hei longjiang Province, Jiamusi | RCT | 2013.4- 2016.4 | HBC | 50 | NA | CG VS. EG | 25 25 | ETV 0.5 mg, once per day, treated for 12 weeks. ETV 0.5 mg, once per day, combined with Tα1 injection 1.6 mg, twice per week, treated for 12 weeks. |
Xu YQ [2017] [21] | Sichuan Province, Leshan | RCT | 2014.1- 2016.12 | DHBC | 60 | NA | CG VS. EG | 30 30 | ETV 0.5 mg, once per day, treated for 48 weeks. ETV 0.5 mg, once per day, combined with Tα1 injection 1.6 mg, twice per week, treated for 48 weeks. |
Zhang XX [2018] [24] | Liaoling Province, Shenyang | RCT | 2014..5- 2017.5 | CHBC | 104 | Guidelines for prevention and treatment of chronic hepatitis B in 2010 | CG VS. EG | 52 52 | ETV 0.5 mg, once per day, treated for 24 weeks. ETV 0.5 mg, once per day, combined with Tα1 injection 1.6 mg, twice per week, treated for 24 weeks. |
Jia P [2017] [20] | Heilong jiang Province, Jiamusi | RCT | 2016.5- 2017.5 | CHBC | 130 | Guidelines for prevention and treatment of chronic hepatitis B in 2015 | CG VS. EG | 65 65 | ETV 0.5 mg, once per day, treated for 6 months. ETV 0.5 mg, once per day, combined with Tα1 injection 1.6 mg, twice per week, treated for 6 months. |