Fig. 2

Pathology a demonstrated the chronic active inflammation of the mucosa in the ileocecal junction. b showed submucosal langerhans giant cells in the colon, considered as granulomatous inflammation. Crypts disappeared in part of the mucous membrane area, but the fissure ulcer was not obvious. Immunohistochemical staining in image c showed moderate intensity staining of inflammatory cells in the lamina propria of the mucosa, mainly plasma cells, neutrophils and monocytes, and the glandular epithelium of the crypts was weakly expressed. d showed moderate intensity staining of inflammatory cells in the lamina propria and the glandular epithelium of the crypts was widely expressed