|
Predictors
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
HR(95% CI)
|
P-value
|
HR(95% CI)
|
P-value
|
|---|
|
Age (years)
|
0.996 (0.980 to 1.013)
|
0.676
| | |
|
BMI (kg/m2)
|
1.028 (0.979 to 1.078)
|
0.268
| | |
|
MAP (mmHg)
|
1.001 (0.985 to 1.018)
|
0.901
| | |
|
Laboratory data
|
|
WBC count (109/L)
|
1.038 (1.010 to 1.066)
|
0.007
| | |
|
Platelet count(109/L)
|
0.998 (0.995 to 1.002)
|
0.306
| | |
|
Total bilirubin (μmol/L)
|
1.000 (0.999 to 1.001)
|
0.498
| | |
|
Albumin(g/L)
|
0.998 (0.967 to 1.030)
|
0.913
| | |
|
INR
|
1.755 (1.455 to 2.118)
|
< 0.001
|
1.482 (1.229 to 1.788)
|
< 0.001
|
|
Creatinine (μmol/L)
|
1.001 (1.000 to 1.003)
|
0.105
| | |
|
Serum sodium (mmol/L)
|
0.983 (0.955 to 1.011)
|
0.233
| | |
|
HBV-DNA level (IU/ml)
|
|
≤ 200
|
1
|
0.126
| | |
|
200–2 × 104
|
0.599 (0.341 to 1.051)
|
0.074
| | |
|
2 × 104–2 × 106
|
0.864 (0.528 to 1.415)
|
0.562
| | |
|
≥ 2 × 106
|
1.151 (0.694 to 1.911)
|
0.586
| | |
|
SIRS
|
1.658 (1.136 to 2.421)
|
0.009
| | |
|
Type of infection(%)
|
|
Pneumonia
|
2.315 (1.563 to 3.429)
|
< 0.001
|
1.904 (1.268 to 2.860)
|
0.002
|
|
SBP
|
0.623 (0.429 to 0.904)
|
0.013
| | |
|
Bacteremia
|
1.260 (0.815 to 1.949)
|
0.299
| | |
|
Number of infection sites
|
|
One
|
1
|
0.132
| | |
|
Two
|
1.184 (0.778 to 1.803)
|
0.430
| | |
|
Three or more
|
1.718 (1.008 to 2.926)
|
0.046
| | |
|
Number of isolated microorganisms
|
|
Zero
|
1
|
0.638
| | |
|
One
|
0.941 (0.625 to 1.418)
|
0.773
| | |
|
Two
|
0.911 (0.456 to 1.819)
|
0.791
| | |
|
Three or more
|
1.375 (0.749 to 2.524)
|
0.304
| | |
|
Complications(%)
|
|
Ascites
|
0.777 (0.585 to 1.031)
|
0.081
| | |
|
Hemorrhage
|
1.447 (0.885 to 2.367)
|
0.141
| | |
|
Acute kidney injury
|
1.456 (1.001 to 2.117)
|
0.049
|
1.529 (1.046 to 2.235)
|
0.028
|
|
HE
|
1.409 (1.214 to 1.636)
|
< 0.001
|
1.263 (1.087 to 1.466)
|
0.002
|
|
Sepsis(%)
|
2.740 (1.756 to 4.273)
|
< 0.001
|
2.166 (1.372 to 3.421)
|
0.001
|
|
Septic shock(%)
|
2.322 (1.612 to 3.345)
|
< 0.001
| | |
- Abbreviations: HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, HR hazard ratio, BMI body mass index, MAP mean arterial pressure, WBC white blood cells, INR international normalized ratio, HBV-DNA hepatitis B virus deoxyribonucleic acid, SIRS system inflammatory reaction syndrome, SBP spontaneous bacterial peritonitis, HE hepatic encephalopathy
