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Table 5 Predictors for 28-day mortality by Cox analysis in HBV-ACLF patients with infection

From: Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

Predictors

Univariate analysis

Multivariate analysis

HR(95% CI)

P-value

HR(95% CI)

P-value

Age (years)

0.996 (0.980 to 1.013)

0.676

  

BMI (kg/m2)

1.028 (0.979 to 1.078)

0.268

  

MAP (mmHg)

1.001 (0.985 to 1.018)

0.901

  

Laboratory data

 WBC count (109/L)

1.038 (1.010 to 1.066)

0.007

  

 Platelet count(109/L)

0.998 (0.995 to 1.002)

0.306

  

 Total bilirubin (μmol/L)

1.000 (0.999 to 1.001)

0.498

  

 Albumin(g/L)

0.998 (0.967 to 1.030)

0.913

  

 INR

1.755 (1.455 to 2.118)

< 0.001

1.482 (1.229 to 1.788)

< 0.001

 Creatinine (μmol/L)

1.001 (1.000 to 1.003)

0.105

  

 Serum sodium (mmol/L)

0.983 (0.955 to 1.011)

0.233

  

 HBV-DNA level (IU/ml)

   ≤ 200

1

0.126

  

  200–2 × 104

0.599 (0.341 to 1.051)

0.074

  

 2 × 104–2 × 106

0.864 (0.528 to 1.415)

0.562

  

   ≥ 2 × 106

1.151 (0.694 to 1.911)

0.586

  

SIRS

1.658 (1.136 to 2.421)

0.009

  

Type of infection(%)

 Pneumonia

2.315 (1.563 to 3.429)

< 0.001

1.904 (1.268 to 2.860)

0.002

 SBP

0.623 (0.429 to 0.904)

0.013

  

 Bacteremia

1.260 (0.815 to 1.949)

0.299

  

Number of infection sites

 One

1

0.132

  

 Two

1.184 (0.778 to 1.803)

0.430

  

 Three or more

1.718 (1.008 to 2.926)

0.046

  

Number of isolated microorganisms

 Zero

1

0.638

  

 One

0.941 (0.625 to 1.418)

0.773

  

 Two

0.911 (0.456 to 1.819)

0.791

  

 Three or more

1.375 (0.749 to 2.524)

0.304

  

Complications(%)

 Ascites

0.777 (0.585 to 1.031)

0.081

  

 Hemorrhage

1.447 (0.885 to 2.367)

0.141

  

 Acute kidney injury

1.456 (1.001 to 2.117)

0.049

1.529 (1.046 to 2.235)

0.028

 HE

1.409 (1.214 to 1.636)

< 0.001

1.263 (1.087 to 1.466)

0.002

Sepsis(%)

2.740 (1.756 to 4.273)

< 0.001

2.166 (1.372 to 3.421)

0.001

Septic shock(%)

2.322 (1.612 to 3.345)

< 0.001

  
  1. Abbreviations: HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, HR hazard ratio, BMI body mass index, MAP mean arterial pressure, WBC white blood cells, INR international normalized ratio, HBV-DNA hepatitis B virus deoxyribonucleic acid, SIRS system inflammatory reaction syndrome, SBP spontaneous bacterial peritonitis, HE hepatic encephalopathy