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Table 5 Predictors for 28-day mortality by Cox analysis in HBV-ACLF patients with infection

From: Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

Predictors Univariate analysis Multivariate analysis
HR(95% CI) P-value HR(95% CI) P-value
Age (years) 0.996 (0.980 to 1.013) 0.676   
BMI (kg/m2) 1.028 (0.979 to 1.078) 0.268   
MAP (mmHg) 1.001 (0.985 to 1.018) 0.901   
Laboratory data
 WBC count (109/L) 1.038 (1.010 to 1.066) 0.007   
 Platelet count(109/L) 0.998 (0.995 to 1.002) 0.306   
 Total bilirubin (μmol/L) 1.000 (0.999 to 1.001) 0.498   
 Albumin(g/L) 0.998 (0.967 to 1.030) 0.913   
 INR 1.755 (1.455 to 2.118) < 0.001 1.482 (1.229 to 1.788) < 0.001
 Creatinine (μmol/L) 1.001 (1.000 to 1.003) 0.105   
 Serum sodium (mmol/L) 0.983 (0.955 to 1.011) 0.233   
 HBV-DNA level (IU/ml)
   ≤ 200 1 0.126   
  200–2 × 104 0.599 (0.341 to 1.051) 0.074   
 2 × 104–2 × 106 0.864 (0.528 to 1.415) 0.562   
   ≥ 2 × 106 1.151 (0.694 to 1.911) 0.586   
SIRS 1.658 (1.136 to 2.421) 0.009   
Type of infection(%)
 Pneumonia 2.315 (1.563 to 3.429) < 0.001 1.904 (1.268 to 2.860) 0.002
 SBP 0.623 (0.429 to 0.904) 0.013   
 Bacteremia 1.260 (0.815 to 1.949) 0.299   
Number of infection sites
 One 1 0.132   
 Two 1.184 (0.778 to 1.803) 0.430   
 Three or more 1.718 (1.008 to 2.926) 0.046   
Number of isolated microorganisms
 Zero 1 0.638   
 One 0.941 (0.625 to 1.418) 0.773   
 Two 0.911 (0.456 to 1.819) 0.791   
 Three or more 1.375 (0.749 to 2.524) 0.304   
Complications(%)
 Ascites 0.777 (0.585 to 1.031) 0.081   
 Hemorrhage 1.447 (0.885 to 2.367) 0.141   
 Acute kidney injury 1.456 (1.001 to 2.117) 0.049 1.529 (1.046 to 2.235) 0.028
 HE 1.409 (1.214 to 1.636) < 0.001 1.263 (1.087 to 1.466) 0.002
Sepsis(%) 2.740 (1.756 to 4.273) < 0.001 2.166 (1.372 to 3.421) 0.001
Septic shock(%) 2.322 (1.612 to 3.345) < 0.001   
  1. Abbreviations: HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, HR hazard ratio, BMI body mass index, MAP mean arterial pressure, WBC white blood cells, INR international normalized ratio, HBV-DNA hepatitis B virus deoxyribonucleic acid, SIRS system inflammatory reaction syndrome, SBP spontaneous bacterial peritonitis, HE hepatic encephalopathy