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Table 4 Predictors for 28-day mortality by Cox analysis in patients with HBV-ACLF

From: Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

Predictors

Univariate analysis

Multivariate analysis

HR(95% CI)

P-value

HR (CI 95%)

P-value

Age (years)

1.001 (0.986 to 1.015)

0.934

  

BMI (kg/m2)

1.022 (0.989 to 1.056)

0.201

  

MAP (mmHg)

1.007 (0.992 to 1.022)

0.376

  

Laboratory data

 WBC count(109/L)

1.045 (1.020 to 1.071)

< 0.001

  

 Platelet count(109/L)

0.999 (0.996 to 1.002)

0.416

  

 Total bilirubin (μmol/L)

1.001 (1.000 to 1.002)

0.072

1.001 (1.000 to 1.002)

0.019

 Albumin(g/L)

0.992 (0.964 to 1.022)

0.599

  

 INR

1.694 (1.420 to 2.021)

< 0.001

1.730 (1.472 to 2.035)

< 0.001

 Creatinine (μmol/L)

1.002 (1.000 to 1.003)

0.022

  

 Serum sodium (mmol/L)

0.977 (0.953 to 1.001)

0.062

  

 HBV-DNA level (IU/ml)

   ≤ 200

1

0.109

  

  200–2 × 104

0.779 (0.488 to 1.245)

0.297

  

  2 × 104–2 × 106

1.090 (0.705 to 1.685)

0.699

  

   ≥ 2 × 106

1.351 (0.867 to 2.107)

0.184

  

Complications(%)

 Infection

1.725 (1.225 to 2.427)

0.002

1.515 (1.071 to 2.144)

0.019

 Ascites

0.868 (0.502 to 1.501)

0.612

  

 Acute kidney injury

1.549 (1.134 to 2.116)

0.006

1.875 (1.365 to 2.577)

< 0.001

 Haemorrhage

1.860 (1.205 to 2.871)

0.005

  

 HE

1.472 (1.295 to 1.674)

< 0.001

1.854 (1.352 to 2.544)

< 0.001

  1. Abbreviations: HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, HR hazard ratio, BMI body mass index, MAP mean arterial pressure, WBC white blood cells, INR international normalized ratio, HBV-DNA hepatitis B virus deoxyribonucleic acid, HE hepatic encephalopathy
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BMC Gastroenterology

ISSN: 1471-230X

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