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Table 4 Predictors for 28-day mortality by Cox analysis in patients with HBV-ACLF

From: Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

Predictors Univariate analysis Multivariate analysis
HR(95% CI) P-value HR (CI 95%) P-value
Age (years) 1.001 (0.986 to 1.015) 0.934   
BMI (kg/m2) 1.022 (0.989 to 1.056) 0.201   
MAP (mmHg) 1.007 (0.992 to 1.022) 0.376   
Laboratory data
 WBC count(109/L) 1.045 (1.020 to 1.071) < 0.001   
 Platelet count(109/L) 0.999 (0.996 to 1.002) 0.416   
 Total bilirubin (μmol/L) 1.001 (1.000 to 1.002) 0.072 1.001 (1.000 to 1.002) 0.019
 Albumin(g/L) 0.992 (0.964 to 1.022) 0.599   
 INR 1.694 (1.420 to 2.021) < 0.001 1.730 (1.472 to 2.035) < 0.001
 Creatinine (μmol/L) 1.002 (1.000 to 1.003) 0.022   
 Serum sodium (mmol/L) 0.977 (0.953 to 1.001) 0.062   
 HBV-DNA level (IU/ml)
   ≤ 200 1 0.109   
  200–2 × 104 0.779 (0.488 to 1.245) 0.297   
  2 × 104–2 × 106 1.090 (0.705 to 1.685) 0.699   
   ≥ 2 × 106 1.351 (0.867 to 2.107) 0.184   
Complications(%)
 Infection 1.725 (1.225 to 2.427) 0.002 1.515 (1.071 to 2.144) 0.019
 Ascites 0.868 (0.502 to 1.501) 0.612   
 Acute kidney injury 1.549 (1.134 to 2.116) 0.006 1.875 (1.365 to 2.577) < 0.001
 Haemorrhage 1.860 (1.205 to 2.871) 0.005   
 HE 1.472 (1.295 to 1.674) < 0.001 1.854 (1.352 to 2.544) < 0.001
  1. Abbreviations: HBV-ACLF hepatitis B virus related acute-on-chronic liver failure, HR hazard ratio, BMI body mass index, MAP mean arterial pressure, WBC white blood cells, INR international normalized ratio, HBV-DNA hepatitis B virus deoxyribonucleic acid, HE hepatic encephalopathy