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Table 1 Baseline characteristics of HBV-ACLF patients with and without infection

From: Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

Variables Infection(n = 185) No infection(n = 104) P-value
Age (years) 48.0 ± 11.0 47.5 ± 10.6 0.731
Male (%) 151 (81.6) 85 (81.7) 0.982
BMI (kg/m2) 24.9 (22.4,27.7) 25.0 (22.1,28.1) 0.990
MAP (mmHg) 85 (79,95) 89 (81,96) 0.028
HBV-DNA level (IU/ml)    0.427
  ≤ 200 41 (22.3) 20 (19.2) 0.543
 200–2 × 104 42 (22.8) 33 (31.7) 0.098
 2 × 104–2 × 106 57 (31.0) 28 (26.9) 0.469
  ≥ 2 × 106 44 (23.9) 23 (22.1) 0.729
Laboratory data
 WBC count (109/L) 9.7 (6.5,13.1) 7.4 (5.5,9.3) < 0.001
 Platelet count (109/L) 64 (40,102) 71 (45,108) 0.201
 Total bilirubin (μmol/L) 339 ± 162 366 ± 155 0.164
 Albumin (g/L) 28.0 (24.0,30.5) 29.0 (26.3,32.0) 0.008
 ALT (U/L) 102 (42,243) 96 (43,199) 0.881
 AST (U/L) 135 (79,278) 128 (84,249) 0.855
 ALP (U/L) 124 (100,169) 142 (110,171) 0.189
 GGT (U/L) 50 (33,78) 49 (34,74) 0.736
 INR 2.4 (1.9,2.8) 2.5 (2.0,2.7) 0.214
 Creatinine (μmol/L) 135 (90,193) 111 (82,147) 0.015
 Serum sodium (mmol/L) 133 (129,137) 133 (128,137) 0.997
 HBeAg (%) 97 (53.0) 50 (48.1) 0.422
 CRP (mg/L) 17.8 (9.1,53.9) 12.8 (8.4,20.8) 0.050
 Procalcitonin (ng/ml) 1.2 (0.5,3.2) 0.6 (0.4,1.1) < 0.001
Complications (%)
 Ascites 171 (92.4) 94 (90.4) 0.545
 Hemorrhage 25 (13.5) 6 (5.8) 0.041
 Acute kidney injury 107 (57.8) 43 (41.3) 0.007
 HE 93 (50.3) 65 (62.5) 0.036
Organ failure (%)
 Liver failure 154 (83.2) 93 (89.4) 0.153
 Coagulation failure 87 (47.0) 60 (57.7) 0.090
 Kidney failure 54 (29.2) 17 (16.3) 0.015
 Cerebral failure 33 (17.8) 6 (5.8) 0.004
 Respiratory failure 24 (13.0) 3 (2.9) 0.005
 Circulation failure 22 (11.9) 1 (1.0) 0.001
Prognostic score
 CLIF-C ACLFs 48 (44,53) 44 (40,48) < 0.001
 CLIF-C OFs 10 (10,12) 10 (9,11) 0.002
 MELD 30 (26,34) 29 (25,32) 0.099
 MELDNa 31 (28,36) 31 (27,34) 0.065
 CTP 13 (12,13) 12 (11,13) 0.066
 SOFA 9 (8,11) 8 (6,9) < 0.001
ACLF grade (%)
 ACLF-1 62 (33.5) 36 (34.6) 0.849
 ACLF-2 80 (43.2) 61 (58.7) 0.012
 ACLF-3 43 (23.2) 7 (6.7) < 0.001
 SIRS (%) 57 (30.8) 12 (11.5) < 0.001
  1. Note: All data are expressed as number (%) or mean ± SD or median (IQR)
  2. Abbreviations: HBV-ACLF: hepatitis B virus related acute-on-chronic liver failure; BMI: body mass index; MAP: mean arterial pressure; HBV-DNA: hepatitis B virus deoxyribonucleic acid; WBC: white blood cells; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transpeptidase; INR: international normalized ratio; HBeAg: hepatitis B virus envelope antigen; CRP: C-reactive protein; HE: hepatic encephalopathy; CLIF-C ACLFs: chronic liver failure consortium acute-on-chronic liver failure score; CLIF-C OFs: chronic liver failure consortium organ failure score; MELD: model for end stage liver disease; CTP: Child-Turcotte-Pugh; SOFA: sequential organ failure assessment; SIRS: system inflammatory reaction syndrome