|
Variables
|
Infection(n = 185)
|
No infection(n = 104)
|
P-value
|
|---|
|
Age (years)
|
48.0 ± 11.0
|
47.5 ± 10.6
|
0.731
|
|
Male (%)
|
151 (81.6)
|
85 (81.7)
|
0.982
|
|
BMI (kg/m2)
|
24.9 (22.4,27.7)
|
25.0 (22.1,28.1)
|
0.990
|
|
MAP (mmHg)
|
85 (79,95)
|
89 (81,96)
|
0.028
|
|
HBV-DNA level (IU/ml)
| | |
0.427
|
|
≤ 200
|
41 (22.3)
|
20 (19.2)
|
0.543
|
|
200–2 × 104
|
42 (22.8)
|
33 (31.7)
|
0.098
|
|
2 × 104–2 × 106
|
57 (31.0)
|
28 (26.9)
|
0.469
|
|
≥ 2 × 106
|
44 (23.9)
|
23 (22.1)
|
0.729
|
|
Laboratory data
|
|
WBC count (109/L)
|
9.7 (6.5,13.1)
|
7.4 (5.5,9.3)
|
< 0.001
|
|
Platelet count (109/L)
|
64 (40,102)
|
71 (45,108)
|
0.201
|
|
Total bilirubin (μmol/L)
|
339 ± 162
|
366 ± 155
|
0.164
|
|
Albumin (g/L)
|
28.0 (24.0,30.5)
|
29.0 (26.3,32.0)
|
0.008
|
|
ALT (U/L)
|
102 (42,243)
|
96 (43,199)
|
0.881
|
|
AST (U/L)
|
135 (79,278)
|
128 (84,249)
|
0.855
|
|
ALP (U/L)
|
124 (100,169)
|
142 (110,171)
|
0.189
|
|
GGT (U/L)
|
50 (33,78)
|
49 (34,74)
|
0.736
|
|
INR
|
2.4 (1.9,2.8)
|
2.5 (2.0,2.7)
|
0.214
|
|
Creatinine (μmol/L)
|
135 (90,193)
|
111 (82,147)
|
0.015
|
|
Serum sodium (mmol/L)
|
133 (129,137)
|
133 (128,137)
|
0.997
|
|
HBeAg (%)
|
97 (53.0)
|
50 (48.1)
|
0.422
|
|
CRP (mg/L)
|
17.8 (9.1,53.9)
|
12.8 (8.4,20.8)
|
0.050
|
|
Procalcitonin (ng/ml)
|
1.2 (0.5,3.2)
|
0.6 (0.4,1.1)
|
< 0.001
|
|
Complications (%)
|
|
Ascites
|
171 (92.4)
|
94 (90.4)
|
0.545
|
|
Hemorrhage
|
25 (13.5)
|
6 (5.8)
|
0.041
|
|
Acute kidney injury
|
107 (57.8)
|
43 (41.3)
|
0.007
|
|
HE
|
93 (50.3)
|
65 (62.5)
|
0.036
|
|
Organ failure (%)
|
|
Liver failure
|
154 (83.2)
|
93 (89.4)
|
0.153
|
|
Coagulation failure
|
87 (47.0)
|
60 (57.7)
|
0.090
|
|
Kidney failure
|
54 (29.2)
|
17 (16.3)
|
0.015
|
|
Cerebral failure
|
33 (17.8)
|
6 (5.8)
|
0.004
|
|
Respiratory failure
|
24 (13.0)
|
3 (2.9)
|
0.005
|
|
Circulation failure
|
22 (11.9)
|
1 (1.0)
|
0.001
|
|
Prognostic score
|
|
CLIF-C ACLFs
|
48 (44,53)
|
44 (40,48)
|
< 0.001
|
|
CLIF-C OFs
|
10 (10,12)
|
10 (9,11)
|
0.002
|
|
MELD
|
30 (26,34)
|
29 (25,32)
|
0.099
|
|
MELDNa
|
31 (28,36)
|
31 (27,34)
|
0.065
|
|
CTP
|
13 (12,13)
|
12 (11,13)
|
0.066
|
|
SOFA
|
9 (8,11)
|
8 (6,9)
|
< 0.001
|
|
ACLF grade (%)
|
|
ACLF-1
|
62 (33.5)
|
36 (34.6)
|
0.849
|
|
ACLF-2
|
80 (43.2)
|
61 (58.7)
|
0.012
|
|
ACLF-3
|
43 (23.2)
|
7 (6.7)
|
< 0.001
|
|
SIRS (%)
|
57 (30.8)
|
12 (11.5)
|
< 0.001
|
- Note: All data are expressed as number (%) or mean ± SD or median (IQR)
- Abbreviations: HBV-ACLF: hepatitis B virus related acute-on-chronic liver failure; BMI: body mass index; MAP: mean arterial pressure; HBV-DNA: hepatitis B virus deoxyribonucleic acid; WBC: white blood cells; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transpeptidase; INR: international normalized ratio; HBeAg: hepatitis B virus envelope antigen; CRP: C-reactive protein; HE: hepatic encephalopathy; CLIF-C ACLFs: chronic liver failure consortium acute-on-chronic liver failure score; CLIF-C OFs: chronic liver failure consortium organ failure score; MELD: model for end stage liver disease; CTP: Child-Turcotte-Pugh; SOFA: sequential organ failure assessment; SIRS: system inflammatory reaction syndrome
