Skip to main content

Table 1 Baseline characteristics of HBV-ACLF patients with and without infection

From: Infection deteriorating hepatitis B virus related acute-on-chronic liver failure: a retrospective cohort study

Variables

Infection(n = 185)

No infection(n = 104)

P-value

Age (years)

48.0 ± 11.0

47.5 ± 10.6

0.731

Male (%)

151 (81.6)

85 (81.7)

0.982

BMI (kg/m2)

24.9 (22.4,27.7)

25.0 (22.1,28.1)

0.990

MAP (mmHg)

85 (79,95)

89 (81,96)

0.028

HBV-DNA level (IU/ml)

  

0.427

  ≤ 200

41 (22.3)

20 (19.2)

0.543

 200–2 × 104

42 (22.8)

33 (31.7)

0.098

 2 × 104–2 × 106

57 (31.0)

28 (26.9)

0.469

  ≥ 2 × 106

44 (23.9)

23 (22.1)

0.729

Laboratory data

 WBC count (109/L)

9.7 (6.5,13.1)

7.4 (5.5,9.3)

< 0.001

 Platelet count (109/L)

64 (40,102)

71 (45,108)

0.201

 Total bilirubin (μmol/L)

339 ± 162

366 ± 155

0.164

 Albumin (g/L)

28.0 (24.0,30.5)

29.0 (26.3,32.0)

0.008

 ALT (U/L)

102 (42,243)

96 (43,199)

0.881

 AST (U/L)

135 (79,278)

128 (84,249)

0.855

 ALP (U/L)

124 (100,169)

142 (110,171)

0.189

 GGT (U/L)

50 (33,78)

49 (34,74)

0.736

 INR

2.4 (1.9,2.8)

2.5 (2.0,2.7)

0.214

 Creatinine (μmol/L)

135 (90,193)

111 (82,147)

0.015

 Serum sodium (mmol/L)

133 (129,137)

133 (128,137)

0.997

 HBeAg (%)

97 (53.0)

50 (48.1)

0.422

 CRP (mg/L)

17.8 (9.1,53.9)

12.8 (8.4,20.8)

0.050

 Procalcitonin (ng/ml)

1.2 (0.5,3.2)

0.6 (0.4,1.1)

< 0.001

Complications (%)

 Ascites

171 (92.4)

94 (90.4)

0.545

 Hemorrhage

25 (13.5)

6 (5.8)

0.041

 Acute kidney injury

107 (57.8)

43 (41.3)

0.007

 HE

93 (50.3)

65 (62.5)

0.036

Organ failure (%)

 Liver failure

154 (83.2)

93 (89.4)

0.153

 Coagulation failure

87 (47.0)

60 (57.7)

0.090

 Kidney failure

54 (29.2)

17 (16.3)

0.015

 Cerebral failure

33 (17.8)

6 (5.8)

0.004

 Respiratory failure

24 (13.0)

3 (2.9)

0.005

 Circulation failure

22 (11.9)

1 (1.0)

0.001

Prognostic score

 CLIF-C ACLFs

48 (44,53)

44 (40,48)

< 0.001

 CLIF-C OFs

10 (10,12)

10 (9,11)

0.002

 MELD

30 (26,34)

29 (25,32)

0.099

 MELDNa

31 (28,36)

31 (27,34)

0.065

 CTP

13 (12,13)

12 (11,13)

0.066

 SOFA

9 (8,11)

8 (6,9)

< 0.001

ACLF grade (%)

 ACLF-1

62 (33.5)

36 (34.6)

0.849

 ACLF-2

80 (43.2)

61 (58.7)

0.012

 ACLF-3

43 (23.2)

7 (6.7)

< 0.001

 SIRS (%)

57 (30.8)

12 (11.5)

< 0.001

  1. Note: All data are expressed as number (%) or mean ± SD or median (IQR)
  2. Abbreviations: HBV-ACLF: hepatitis B virus related acute-on-chronic liver failure; BMI: body mass index; MAP: mean arterial pressure; HBV-DNA: hepatitis B virus deoxyribonucleic acid; WBC: white blood cells; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; GGT: gamma-glutamyl transpeptidase; INR: international normalized ratio; HBeAg: hepatitis B virus envelope antigen; CRP: C-reactive protein; HE: hepatic encephalopathy; CLIF-C ACLFs: chronic liver failure consortium acute-on-chronic liver failure score; CLIF-C OFs: chronic liver failure consortium organ failure score; MELD: model for end stage liver disease; CTP: Child-Turcotte-Pugh; SOFA: sequential organ failure assessment; SIRS: system inflammatory reaction syndrome
Back to article page

BMC Gastroenterology

ISSN: 1471-230X

Contact us