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Table 2 Relationship between patient characteristics and the development or regression of nonalcoholic fatty liver disease

From: The association of genetic polymorphisms with nonalcoholic fatty liver disease in a longitudinal study

  No development of NAFLD
(N = 3031)
Development of NAFLD
(N = 874)
P-Value No regression of NAFLD
(N = 1482)
Regression of NAFLD
(N = 336)
P-Value
Age (years) 48.3 ± 10.3 50.2 ± 9.6 < 0.001 51.2 ± 9.5 52.7 ± 10.3 0.012
Male, n (%) 1206 (39.8) 505 (57.8) < 0.001 1184 (79.9) 242 (72.0) 0.002
Diabetes mellitus, n (%) 44 (1.5) 52 (5.9) < 0.001 151 (10.2) 24 (7.1) 0.087
Hypertension, n (%) 308 (10.2) 150 (17.2) < 0.001 397 (26.8) 76 (22.6) 0.116
Systolic blood pressure (mmHg) 112.0 ± 12.9 116.7 ± 13.3 < 0.001 119.3 ± 12.2 116.2 ± 12.7 < 0.001
Diastolic blood pressure (mmHg) 73.0 ± 9.9 76.7 ± 10.0 < 0.001 79.5 ± 9.4 76.2 ± 9.4 < 0.001
Body mass index (kg/m2) 21.6 ± 2.4 23.8 ± 2.5 < 0.001 25.2 ± 2.7 23.6 ± 2.6 < 0.001
Waist circumference (cm) 77.9 ± 7.4 84.7 ± 6.9 < 0.001 88.9 ± 7.1 84.8 ± 7.2 < 0.001
AST (IU/L) 21.3 ± 8.8 22.3 ± 7.7 0.001 25.9 ± 12.1 22.5 ± 7.6 < 0.001
ALT (IU/L) 18.1 ± 11.4 23.2 ± 13.5 < 0.001 31.6 ± 20.1 22.7 ± 11.4 < 0.001
Cholesterol (mg/dL) 191.4 ± 31.8 197.8 ± 35.3 < 0.001 194.7 ± 36.3 190.2 ± 34.7 0.035
Triglycerides (mg/dL) 82.6 ± 44.8 117.9 ± 64.6 < 0.001 146.2 ± 91.8 112.2 ± 57.6 < 0.001
HDL cholesterol (mg/dL) 57.6 ± 12.2 51.8 ± 10.7 < 0.001 47.9 ± 9.2 51.8 ± 11.1 < 0.001
Fasting glucose (mg/dL) 93.4 ± 11.8 100.1 ± 14.9 < 0.001 105.7 ± 21.0 100.6 ± 16.4 < 0.001
Elevation in ALT levels, n (%) 332/2091 (15.9) 178/629 (28.3) < 0.001    
Reduction in ALT levels, n (%)     214/454 (47.1) 69/92 (75.0) < 0.001
  1. Data are shown as the mean ± SD
  2. NAFLD nonalcoholic fatty liver disease, AST aspartate aminotransferase, ALT alanine aminotransferase, HDL high-density lipoprotein