No development of NAFLD (N = 3031) | Development of NAFLD (N = 874) | P-Value | No regression of NAFLD (N = 1482) | Regression of NAFLD (N = 336) | P-Value | |
---|---|---|---|---|---|---|
Age (years) | 48.3 ± 10.3 | 50.2 ± 9.6 | < 0.001 | 51.2 ± 9.5 | 52.7 ± 10.3 | 0.012 |
Male, n (%) | 1206 (39.8) | 505 (57.8) | < 0.001 | 1184 (79.9) | 242 (72.0) | 0.002 |
Diabetes mellitus, n (%) | 44 (1.5) | 52 (5.9) | < 0.001 | 151 (10.2) | 24 (7.1) | 0.087 |
Hypertension, n (%) | 308 (10.2) | 150 (17.2) | < 0.001 | 397 (26.8) | 76 (22.6) | 0.116 |
Systolic blood pressure (mmHg) | 112.0 ± 12.9 | 116.7 ± 13.3 | < 0.001 | 119.3 ± 12.2 | 116.2 ± 12.7 | < 0.001 |
Diastolic blood pressure (mmHg) | 73.0 ± 9.9 | 76.7 ± 10.0 | < 0.001 | 79.5 ± 9.4 | 76.2 ± 9.4 | < 0.001 |
Body mass index (kg/m2) | 21.6 ± 2.4 | 23.8 ± 2.5 | < 0.001 | 25.2 ± 2.7 | 23.6 ± 2.6 | < 0.001 |
Waist circumference (cm) | 77.9 ± 7.4 | 84.7 ± 6.9 | < 0.001 | 88.9 ± 7.1 | 84.8 ± 7.2 | < 0.001 |
AST (IU/L) | 21.3 ± 8.8 | 22.3 ± 7.7 | 0.001 | 25.9 ± 12.1 | 22.5 ± 7.6 | < 0.001 |
ALT (IU/L) | 18.1 ± 11.4 | 23.2 ± 13.5 | < 0.001 | 31.6 ± 20.1 | 22.7 ± 11.4 | < 0.001 |
Cholesterol (mg/dL) | 191.4 ± 31.8 | 197.8 ± 35.3 | < 0.001 | 194.7 ± 36.3 | 190.2 ± 34.7 | 0.035 |
Triglycerides (mg/dL) | 82.6 ± 44.8 | 117.9 ± 64.6 | < 0.001 | 146.2 ± 91.8 | 112.2 ± 57.6 | < 0.001 |
HDL cholesterol (mg/dL) | 57.6 ± 12.2 | 51.8 ± 10.7 | < 0.001 | 47.9 ± 9.2 | 51.8 ± 11.1 | < 0.001 |
Fasting glucose (mg/dL) | 93.4 ± 11.8 | 100.1 ± 14.9 | < 0.001 | 105.7 ± 21.0 | 100.6 ± 16.4 | < 0.001 |
Elevation in ALT levels, n (%) | 332/2091 (15.9) | 178/629 (28.3) | < 0.001 | |||
Reduction in ALT levels, n (%) | 214/454 (47.1) | 69/92 (75.0) | < 0.001 |