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Table 2 Relationship between patient characteristics and the development or regression of nonalcoholic fatty liver disease

From: The association of genetic polymorphisms with nonalcoholic fatty liver disease in a longitudinal study

 

No development of NAFLD

(N = 3031)

Development of NAFLD

(N = 874)

P-Value

No regression of NAFLD

(N = 1482)

Regression of NAFLD

(N = 336)

P-Value

Age (years)

48.3 ± 10.3

50.2 ± 9.6

< 0.001

51.2 ± 9.5

52.7 ± 10.3

0.012

Male, n (%)

1206 (39.8)

505 (57.8)

< 0.001

1184 (79.9)

242 (72.0)

0.002

Diabetes mellitus, n (%)

44 (1.5)

52 (5.9)

< 0.001

151 (10.2)

24 (7.1)

0.087

Hypertension, n (%)

308 (10.2)

150 (17.2)

< 0.001

397 (26.8)

76 (22.6)

0.116

Systolic blood pressure (mmHg)

112.0 ± 12.9

116.7 ± 13.3

< 0.001

119.3 ± 12.2

116.2 ± 12.7

< 0.001

Diastolic blood pressure (mmHg)

73.0 ± 9.9

76.7 ± 10.0

< 0.001

79.5 ± 9.4

76.2 ± 9.4

< 0.001

Body mass index (kg/m2)

21.6 ± 2.4

23.8 ± 2.5

< 0.001

25.2 ± 2.7

23.6 ± 2.6

< 0.001

Waist circumference (cm)

77.9 ± 7.4

84.7 ± 6.9

< 0.001

88.9 ± 7.1

84.8 ± 7.2

< 0.001

AST (IU/L)

21.3 ± 8.8

22.3 ± 7.7

0.001

25.9 ± 12.1

22.5 ± 7.6

< 0.001

ALT (IU/L)

18.1 ± 11.4

23.2 ± 13.5

< 0.001

31.6 ± 20.1

22.7 ± 11.4

< 0.001

Cholesterol (mg/dL)

191.4 ± 31.8

197.8 ± 35.3

< 0.001

194.7 ± 36.3

190.2 ± 34.7

0.035

Triglycerides (mg/dL)

82.6 ± 44.8

117.9 ± 64.6

< 0.001

146.2 ± 91.8

112.2 ± 57.6

< 0.001

HDL cholesterol (mg/dL)

57.6 ± 12.2

51.8 ± 10.7

< 0.001

47.9 ± 9.2

51.8 ± 11.1

< 0.001

Fasting glucose (mg/dL)

93.4 ± 11.8

100.1 ± 14.9

< 0.001

105.7 ± 21.0

100.6 ± 16.4

< 0.001

Elevation in ALT levels, n (%)

332/2091 (15.9)

178/629 (28.3)

< 0.001

   

Reduction in ALT levels, n (%)

   

214/454 (47.1)

69/92 (75.0)

< 0.001

  1. Data are shown as the mean ± SD
  2. NAFLD nonalcoholic fatty liver disease, AST aspartate aminotransferase, ALT alanine aminotransferase, HDL high-density lipoprotein