Fig. 2

Manhattan plot of genome-wide association signals between SNPs and NAFLD (a) and a quantile–quantile plot (b) for the discovery set. In the Manhattan plot, the x-axis represents the SNP markers on each chromosome. The y-axis shows the -log10 p-value (logistic regression). The red horizontal line indicates the Bonferroni-adjusted significance threshold (5 × 10⁻⁸), and the blue horizontal line represents the genome-wide suggestiveness threshold (p = 1E-04). In the quantile–quantile plot, the x-axis and y-axis indicate the negative log-scale of the expected p-values for each SNP and the negative log-scale of the observed p-values, respectively. A straight line indicates the expected results under Hardy-Weinberg equilibrium